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Systems Biology

BetaSys

Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

Editors: Booß-Bavnbek, B., Kloesgen, B., Larsen, J., Pociot, F., Renström, E. (Eds.)

  • Uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications
  • In using a focused approach here by picking one outlook, the topic of Systems Biology is made more accessible
  • Systems Biology is a fast moving field, but the work presented here emphasizes the principal aspects of the field, making this a tool for on-going research
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eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-6956-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-4419-6955-2
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-4614-2815-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.

Reviews

From the reviews:

“This second volume is Springer’s Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. … I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research.” (P. Meda, Diabetologia, Vol. 54, 2011)

Table of contents (23 chapters)

  • Systems Biology of the β-Cell – Revisited

    Pociot, Flemming

    Pages 3-23

  • Established Facts and Open Questions of Regulated Exocytosis in β-Cells – A Background for a Focused Systems Analysis Approach

    Renström, Erik

    Pages 25-52

  • Mitochondria and Metabolic Signals in β-Cells

    Maechler, Pierre

    Pages 53-71

  • β-Cell Ontogenesis and the Insulin Production Apparatus

    Heller, R. Scott (et al.)

    Pages 73-81

  • The Role of the Cytoskeleton in Transport and Release of Insulin-Containing Granules by Pancreatic β-Cells

    Goody, Roger S. (et al.)

    Pages 83-95

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-6956-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-4419-6955-2
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-4614-2815-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
BetaSys
Book Subtitle
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Editors
  • Bernhelm Booß-Bavnbek
  • Beate Kloesgen
  • Jesper Larsen
  • Flemming Pociot
  • Erik Renström
Series Title
Systems Biology
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6956-9
DOI
10.1007/978-1-4419-6956-9
Hardcover ISBN
978-1-4419-6955-2
Softcover ISBN
978-1-4614-2815-2
Series ISSN
2191-222X
Edition Number
1
Number of Pages
XX, 556
Topics