Multiscale Approaches to Protein Modeling

Editors: Kolinski, Andrzej (Ed.)

  • Contains comprehensive reviews of the most advanced multiscale modeling methods in protein structure prediction
  • Presents a wide range of approaches to the levels of coarse-grained representations
  • Can be used as a reference book for those who just are beginning with biomacromolecular modeling, and also as a source of more detailed information for experts in the field
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  • ISBN 978-1-4419-6889-0
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Hardcover $259.00
price for USA
  • ISBN 978-1-4419-6888-3
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Softcover $259.00
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  • ISBN 978-1-4899-8236-0
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About this book

Multiscale Approaches to Protein Modeling is a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. The approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. Thanks to enormous progress in sequencing of genomic data, we presently know millions of protein sequences. At the same time, the number of experimentally solved protein structures is much smaller, ca. 60,000. This is because of the large cost of structure determination. Thus, theoretical, in silico, prediction of protein structures and dynamics is essential for understanding the molecular basis of drug action, metabolic and signaling pathways in living cells, designing new technologies in the life science and material sciences. Unfortunately, a “brute force” approach remains impractical. Folding of a typical protein (in vivo or in vitro) takes milliseconds to minutes, while state-of-the-art all-atom molecular mechanics simulations of protein systems can cover only a time period range of nanosecond to microseconds. This is the reason for the enormous progress in development of various mutiscale modeling techniques, applied to protein structure prediction, modeling of protein dynamics and folding pathways, in silico protein engineering, model-aided interpretation of experimental data, modeling of macromolecular assemblies and theoretical studies of protein thermodynamics. Coarse-graining of the proteins’ conformational space is a common feature of all these approaches, although the details and the underlying physical models span a very broad spectrum.

Table of contents (14 chapters)

  • Lattice Polymers and Protein Models

    Kolinski, Andrzej

    Pages 1-20

  • Multiscale Protein and Peptide Docking

    Kurcinski, Mateusz (et al.)

    Pages 21-33

  • Coarse-Grained Models of Proteins: Theory and Applications

    Czaplewski, Cezary (et al.)

    Pages 35-83

  • Conformational Sampling in Structure Prediction and Refinement with Atomistic and Coarse-Grained Models

    Feig, Michael (et al.)

    Pages 85-109

  • Effective All-Atom Potentials for Proteins

    Irbäck, Anders (et al.)

    Pages 111-126

Buy this book

eBook $199.00
price for USA
  • ISBN 978-1-4419-6889-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-6888-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8236-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Multiscale Approaches to Protein Modeling
Editors
  • Andrzej Kolinski
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6889-0
DOI
10.1007/978-1-4419-6889-0
Hardcover ISBN
978-1-4419-6888-3
Softcover ISBN
978-1-4899-8236-0
Edition Number
1
Number of Pages
XII, 355
Topics