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Environmental Factors, Genes, and the Development of Human Cancers

Editors: Roy, Deodutta, Dorak, M. Tevfik (Eds.)

  • This book addresses the effects of environment on the etiology, development and the susceptibility of human cancer.

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eBook $199.00
price for USA
  • ISBN 978-1-4419-6752-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-6751-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8219-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.

Table of contents (17 chapters)

  • Introduction

    Roy, Deodutta (et al.)

    Pages 3-9

  • Gene–Environment Interactions, Phenotypic Changes, and Human Health

    Ramos, Rosemarie G. (et al.)

    Pages 11-51

  • Statistics for Testing Gene–Environment Interaction

    Xiong, Momiao (et al.)

    Pages 53-95

  • Clustering Studies for Identifying the Role of Environmental Factors in Aetiology of Human Cancers

    McNally, Richard J.Q.

    Pages 97-114

  • Discovering Gene–Gene and Gene–Environment Causal Interactions Using Bioinformatics Approaches

    Yoo, Changwon

    Pages 115-138

Buy this book

eBook $199.00
price for USA
  • ISBN 978-1-4419-6752-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-6751-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-8219-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Environmental Factors, Genes, and the Development of Human Cancers
Editors
  • Deodutta Roy
  • M. Tevfik Dorak
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6752-7
DOI
10.1007/978-1-4419-6752-7
Hardcover ISBN
978-1-4419-6751-0
Softcover ISBN
978-1-4899-8219-3
Edition Number
1
Number of Pages
XIII, 520
Topics