Cancer Drug Discovery and Development

The Tumor Microenvironment

Editors: Bagley, Rebecca G. (Ed.)

  • Explains role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination
  • Represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment
  • In-depth chapters written by known professionals in the field
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eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-6615-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-1-4419-6614-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.00
price for USA
  • ISBN 978-1-4614-2660-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The field of cancer biology and developmental therapeutics is continually evolving as new methodologies are developed and new targets are discovered. Although multiple therapeutics directly target the malignant cells these drugs rarely prevent recurrence of disease or the progression of metastasis. The complex biology of tumors presents challenges in designing treatments that will eliminate the malignant cells as well as the supporting network of vasculature and stroma that allows for the comparison of tumors to developing organs in embryos. In addition to blood vessels and malignant cells, tumors consist of fibroblasts, immune and inflammatory cells, and a myriad of proteins that comprise the extracellular matrix. Effective eradication of malignant disease requires therapeutic strategies that factor in targeting the tumor microenvironment. In the past decade, a new class of anticancer drugs has emerged that interferes with tumor angiogenesis; however the clinical benefit from treatment with the first generation antiangiogenic agents added to the standard of care is often modest. Thus, there remains a critical need to understand the tumor microenvironment and to develop anti-cancer therapies that address this aspect of malignant disease. The first edition of The Tumor Microenvironment is intended to give a current perspective on the role of the tumor microenvironment in malignant progression and detail strategies for novel therapies directed towards the cellular matrix. This book explores the many biological and physiological aspects of the tumor as a tissue and includes chapters on the variety of cells that influence tumor growth and spread as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters describe endothelial cells and pericytes that form tumor vasculature. Insights into the role of progenitor and stem cells are included. The contribution of the supporting stroma is addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters describe the influence of infiltrating cells of the immune system on tumor growth. The Tumor Microenvironment is the definitive text detailing cutting edge research by experts in the field and will be a valued resource in the study of this important area of cancer biology for many years to come.

About the authors

Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.

Table of contents (32 chapters)

  • Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy

    Rapisarda, Annamaria (et al.)

    Pages 3-21

  • The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases

    Swietach, Pawel (et al.)

    Pages 23-41

  • Hypoxia, Gene Expression, and Metastasis

    Razorenova, Olga V. (et al.)

    Pages 43-58

  • Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX

    Pastorek, Jaromir (et al.)

    Pages 59-90

  • Glycolytic Pathway as a Target for Tumor Inhibition

    Lu, Weiqin (et al.)

    Pages 91-118

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-6615-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-1-4419-6614-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.00
price for USA
  • ISBN 978-1-4614-2660-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Tumor Microenvironment
Editors
  • Rebecca G. Bagley
Series Title
Cancer Drug Discovery and Development
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-6615-5
DOI
10.1007/978-1-4419-6615-5
Hardcover ISBN
978-1-4419-6614-8
Softcover ISBN
978-1-4614-2660-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVIII, 770
Topics