Molecular Pathology of Hematolymphoid Diseases

1. Front Matter

   Pages i-xv

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2. Molecular Pathology of Hematolymphoid Neoplasms: General Principles

   1. Front Matter

      Pages 1-1

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   2. Molecular Oncogenesis

      • Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, Falko Fend

      Pages 3-19

   3. Genetic Predispositions for Hematologic and Lymphoid Disorders

      • Frederick G. Behm

      Pages 21-64

   4. Prognostic Markers

      • David Bahler

      Pages 65-72

   5. Cancer Stem Cells: Potential Targets for Molecular Medicine

      • Isabel G. Newton, Catriona H. M. Jamieson

      Pages 73-80

   6. Gene Therapy for Leukemia and Lymphoma

      • Xiaopei Huang, Yiping Yang

      Pages 81-89

   7. Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression)

      • Richard J. Q. McNally

      Pages 91-106

   8. Viral Oncogenesis

      • Alexander A. Benders, Margaret L. Gulley

      Pages 107-116

3. Specific Techniques and Their Applications in Molecular Hematopathology

   1. Front Matter

      Pages 118-118

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   2. Techniques to Determine Clonality in Hematolymphoid Malignancies

      • Daniel E. Sabath

      Pages 119-128

   3. Techniques to Detect Defining Chromosomal Translocations/Abnormalities

      • Jennifer J. D. Morrissette, Karen Weck, Cherie H. Dunphy

      Pages 129-152

   4. Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease

      • Marie E. Beckner, Jeffrey A. Kant

      Pages 153-164

   5. Detection of Resistance to Therapy in Hematolymphoid Neoplasms

      • Karen Weck

      Pages 165-171

   6. Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting

      • Jessica K. Booker

      Pages 173-176

   7. Gene Expression Profiling

      • Cherie H. Dunphy

      Pages 177-189

   8. Proteomics of Human Malignant Lymphoma

      • Megan S. Lim, Rodney R. Miles, Kojo S. J. Elenitoba-Johnson

      Pages 191-202

   9. Mouse Models of Hematolymphoid Malignancies

      • Krista M. D. La Perle, Suzana S. Couto

      Pages 203-208

4. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes

   1. Front Matter

      Pages 210-210

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   2. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

      • Patricia Aoun

      Pages 211-220

The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.

• bone marrow
• cancer
• chromosome
• diagnostics
• gene expression
• gene therapy
• genetics
• genome
• internal medicine
• lymphoma
• molecular biology
• molecular genetics
• molecular pathology
• pathogenesis
• stem cells

• Dept. Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, USA

  Cherie H. Dunphy

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