Advances in Experimental Medicine and Biology

Recent Advances on Model Hosts

Editors: Mylonakis, E., Ausubel, F.M., Gilmore, M., Casadevall, A. (Eds.)

  • Provides a series of reports from the 1st International Conference on Model Hosts, the first meeting of its kind
  • Focuses on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions
  • Full-color figures illustrate complex concepts
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Hardcover $259.00
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About this book

Most studies of bacterial or fungal infectious diseases focus separately on the pathogenic microbe, the host response, or the characterization of therapeutic compounds. Compartmentalization of pathogenesis-related research into an analysis of the “pathogen”, the “host,” or the “antimicrobial compound” has largely been dictated by the lack of model systems in which all of these approaches can be used simultaneously, as well as by the traditional view that microbiology, immunology, and chemical biology and pharmacology are separate disciplines. An increasing number of workers from different fields have turned to insects, fish, worms and other model hosts as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases and to study host responses and innate immunity. Because many of these hosts are genetically tractable, they can be used in conjunction with an appropriate pathogen to facilitate the discovery of novel features of the host innate immune response.

This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals.

This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals.

Table of contents (11 chapters)

  • Amoeba Provide Insight into the Origin of Virulence in Pathogenic Fungi

    Casadevall, Arturo

    Pages 1-10

  • Of Model Hosts and Man: Using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as Model Hosts for Infectious Disease Research

    Glavis-Bloom, Justin (et al.)

    Pages 11-17

  • Caenorhabditis elegans as an Alternative Model to Study Senescence of Host Defense and the Prevention by Immunonutrition

    Komura, Tomomi (et al.)

    Pages 19-27

  • Bacterial Effectors: Learning on the Fly

    Boyer, Laurent (et al.)

    Pages 29-36

  • A Drosophila Asthma Model – What the Fly Tells Us About Inflammatory Diseases of the Lung

    Roeder, Thomas (et al.)

    Pages 37-47

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-5638-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-5637-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Recent Advances on Model Hosts
Editors
  • Eleftherios Mylonakis
  • Frederick M. Ausubel
  • Michael Gilmore
  • Arturo Casadevall
Series Title
Advances in Experimental Medicine and Biology
Series Volume
710
Copyright
2012
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-5638-5
DOI
10.1007/978-1-4419-5638-5
Hardcover ISBN
978-1-4419-5637-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VI, 136
Topics