Current Cancer Research

Cell Cycle Deregulation in Cancer

Editors: Enders, Greg H. (Ed.)

  • Includes 11 reviews by leading experts in tumorigenesis
  • Outlines major cell cycle perturbations that drive tumorigenesis
  • Explores the prospects for using such knowledge in cancer therapy
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eBook $199.00
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  • ISBN 978-1-4419-1770-6
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Hardcover $259.00
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  • ISBN 978-1-4419-1769-0
  • Free shipping for individuals worldwide
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Softcover $259.00
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  • ISBN 978-1-4614-2569-4
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About this book

Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinases (Cdks) to drive major cell cycle transitions. Much has been learned since about how these and other proteins control cell cycle progression in all eukaryotes, including man. Further research is uncovering how these controls are de-regulated in cancer, a disease of unbridled cell proliferation that is the leading cause of death in developed countries. However, there is much more to be learned, and the hard won gains are just beginning to impact cancer care. In 11 reviews by leading experts, this volume lays out the current state and directions of the field for biomedical scientists of all training levels.

The collection begins with three reviews that delineate how cells initiate the cell cycle, from growth factor stimulation to activation of key transcription programs and origins of DNA replication. The next three reviews address issues of proliferation under duress, including how derangement of mitotic checkpoints can lead to cell death or genetic instability and how recycling of intracellular molecules (autophagy) is regulated. The next three reviews address the special context of long-term proliferation—how it is regulated in stem cells, how it can erode telomeric structures on the tips of chromosomes, and how it can culminate in senescence. The last two reviews describe how cell cycle advances are beginning to touch patients, in the characterization of pre-malignant states and in cancer therapy.

Table of contents (11 chapters)

  • Escape from Cellular Quiescence

    Sotillo, Elena (et al.)

    Pages 3-22

  • Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription

    Ji, Jun-Yuan (et al.)

    Pages 23-41

  • Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs

    McClendon, A. Kathleen (et al.)

    Pages 43-55

  • Mitotic Checkpoint and Chromosome Instability in Cancer

    Huang, Haomin (et al.)

    Pages 59-77

  • Mitotic Catastrophe

    Chow, Jeremy P.H. (et al.)

    Pages 79-96

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4419-1770-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4419-1769-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4614-2569-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell Cycle Deregulation in Cancer
Editors
  • Greg H. Enders
Series Title
Current Cancer Research
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-1770-6
DOI
10.1007/978-1-4419-1770-6
Hardcover ISBN
978-1-4419-1769-0
Softcover ISBN
978-1-4614-2569-4
Series ISSN
2199-2584
Edition Number
1
Number of Pages
VIII, 206
Number of Illustrations and Tables
8 b/w illustrations, 11 illustrations in colour
Topics