Molecular Basis for Therapy of AIDS-Defining Cancers

Editors: Dittmer, Dirk P., Krown, Susan E. (Eds.)

  • Provides an update of the latest treatments for AIDS defining cancers, a scientific rationale for established treatments and a review of novel molecularly-targeted treatment options, which have passed pre-clinical testing

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eBook $189.00
price for USA (gross)
  • ISBN 978-1-4419-1513-9
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  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4419-1512-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-8200-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

An increased risk for various cancers is a characteristic of people living with HIV infection.  Although only three cancers – Kaposi’s sarcoma, high-grade B-cell lymphomas, and invasive cervical cancer – are considered to be "AIDS-defining" conditions, are associated with oncogenic viruses, and occur with increased frequency as immune function declines, other cancer types also occur significantly more frequently in HIV-positive individuals than in the general population, but are not directly associated with clinical progression to AIDS. Notably these "non-AIDS-defining" cancers include virus-associated cancers such as anal cancer, hepatocellular cancer and Hodgkin’s disease, as well as non-virus associated cancers such as lung cancer. Importantly, there are also large worldwide differences in the incidence and behavior of different AIDS-associated cancers.

 

Although effective combination antiretroviral therapy (cART) may be sufficient in some cases to decrease the incidence or beneficially influence the course of some cancers, in other cases it fails to control cancers in people living with HIV/AIDS. Currently, more than a decade after the widespread introduction of cART, and after major advances in the basic understanding of cancer signaling pathways, we have a unique opportunity to revisit the pathobiology, epidemiology and treatment options for malignancies in people living with HIV/AIDS. Molecular Basis for Therapy of AIDS-Defining Cancers provides a primer on the science of cancer in the setting of HIV infection, as well as examples of novel treatment approaches for HIV-associated neoplasia.

Table of contents (14 chapters)

  • The Epidemiology of Cancer in People with HIV

    Grulich, Andrew E. (et al.)

    Pages 1-16

  • Epidemiology and Clinical Characteristics of Non-AIDS-Defining Malignancies

    Chiao, Elizabeth Y.

    Pages 17-40

  • HIV-Related Cancer Management in Resource-Limited Settings: A Case Study of Malawi

    Hosseinipour, Mina C.

    Pages 41-58

  • Immunology of HIV-Associated Kaposi Sarcoma

    Cattamanchi, Ashok (et al.)

    Pages 59-78

  • Targeting Signal Transduction Pathways for the Treatment of Kaposi Sarcoma

    Douglas, Janet L. (et al.)

    Pages 79-93

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4419-1513-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-1-4419-1512-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4899-8200-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Basis for Therapy of AIDS-Defining Cancers
Editors
  • Dirk P. Dittmer
  • Susan E. Krown
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-1-4419-1513-9
DOI
10.1007/978-1-4419-1513-9
Hardcover ISBN
978-1-4419-1512-2
Softcover ISBN
978-1-4899-8200-1
Edition Number
1
Number of Pages
XIII, 256
Topics