Cellular Senescence and Tumor Suppression

Editors: Adams, Peter D., Sedivy, John M. (Eds.)

  • Will cover many of the recent findings in the area of senescence and cancer, including chapters that discuss telomeres and senescence signals, the senescent phenotype, and the physiological effects of senescence, including therapeutic applications

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4419-1075-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4419-1074-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8356-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest.

Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself, but rather, senescent cells influence their environment and neighboring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process.

Cellular Senescence and Tumor Suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions, with a particular emphasis on the role of senescence in tumor suppression.

Table of contents (10 chapters)

  • Telomere Biology and Biochemistry

    Gardano, Laura (et al.)

    Pages 3-43

  • Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance

    Ghosh, Avik (et al.)

    Pages 45-62

  • Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses

    Bourdeau, VĂ©ronique (et al.)

    Pages 63-83

  • Stress-Induced Senescence

    Hornsby, Peter J.

    Pages 85-106

  • The Secretome of Senescent Cells

    Banumathy, Gowrishankar (et al.)

    Pages 109-123

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4419-1075-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4419-1074-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8356-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Cellular Senescence and Tumor Suppression
Editors
  • Peter D. Adams
  • John M. Sedivy
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-1075-2
DOI
10.1007/978-1-4419-1075-2
Hardcover ISBN
978-1-4419-1074-5
Softcover ISBN
978-1-4899-8356-5
Edition Number
1
Number of Pages
XIII, 272
Topics