Cell-Extracellular Matrix Interactions in Cancer

Editors: Zent, Roy, Pozzi, Ambra (Eds.)

  • Will discuss how integrins and extracellular matrix components control cancer initiation, progression and metastasis

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eBook $169.00
price for USA (gross)
  • ISBN 978-1-4419-0814-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4419-0813-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8112-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions.

Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.

Table of contents (12 chapters)

  • The Extracellular Matrix: An Overview

    Miner, Jeffrey H.

    Pages 1-17

  • Integrin Structure and Function

    Srichai, Manakan Betsy (et al.)

    Pages 19-41

  • Cancer in Context: Importance of the Tumor Microenvironment

    Fingleton, Barbara (et al.)

    Pages 43-63

  • Basement Membrane Collagens and Cancer

    Pedchenko, Vadim (et al.)

    Pages 65-85

  • Laminins and Cancer Progression

    Jourquin, Jerome (et al.)

    Pages 87-109

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4419-0814-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4419-0813-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-1-4899-8112-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cell-Extracellular Matrix Interactions in Cancer
Editors
  • Roy Zent
  • Ambra Pozzi
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-0814-8
DOI
10.1007/978-1-4419-0814-8
Hardcover ISBN
978-1-4419-0813-1
Softcover ISBN
978-1-4899-8112-7
Edition Number
1
Number of Pages
XII, 314
Topics