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Cell-Extracellular Matrix Interactions in Cancer

  • Book
  • © 2010

Overview

Editors:
  1. Roy Zent

    1. Vanderbilt University Medical Center, Department of Medicine, Nashville, U.S.A.

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    You can also search for this editor in PubMed   Google Scholar

  2. Ambra Pozzi

    1. Medical Center, Vanderbilt University, Nashville, U.S.A.

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Will discuss how integrins and extracellular matrix components control cancer initiation, progression and metastasis

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. The Extracellular Matrix: An Overview

    • Jeffrey H. Miner
    Pages 1-17

  3. Integrin Structure and Function

    • Manakan Betsy Srichai, Roy Zent
    Pages 19-41

  4. Cancer in Context: Importance of the Tumor Microenvironment

    • Barbara Fingleton, Conor Lynch
    Pages 43-63

  5. Basement Membrane Collagens and Cancer

    • Vadim Pedchenko, Ambra Pozzi
    Pages 65-85

  6. Laminins and Cancer Progression

    • Jerome Jourquin, Manisha Tripathi, Cherise Guess, Vito Quaranta
    Pages 87-109

  7. Fibronectins and Their Receptors in Cancer

    • Christie J. Avraamides, Judith A. Varner
    Pages 111-136

  8. Vitronectin-Binding Integrins in Cancer

    • Eric Murphy, Dwayne Stupack
    Pages 137-170

  9. The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction

    • Rolf A. Brekken, Amy D. Bradshaw
    Pages 171-189

  10. Proteoglycans and Cancer

    • Ralph D. Sanderson, Yang Yang, Anurag Purushothaman, Yekaterina B. Khotskaya, Joseph P. Ritchie, Vishnu C. Ramani
    Pages 191-215

  11. Tetraspanins in Cancer

    • Andries Zijlstra
    Pages 217-243

  12. The Role of Integrin-Linked Kinase in Cancer Development and Progression

    • Paul C. McDonald, Shoukat Dedhar
    Pages 245-273

  13. Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer

    • Vita M. Golubovskaya, Elizabeth A. Beierle, Steven N. Hochwald, Elena V. Kurenova, William G. Cance
    Pages 275-305

  14. Back Matter

    Pages 307-314
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Keywords

About this book

Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Editors and Affiliations

  • Vanderbilt University Medical Center, Department of Medicine, Nashville, U.S.A.

    Roy Zent

  • Medical Center, Vanderbilt University, Nashville, U.S.A.

    Ambra Pozzi

Bibliographic Information

  • Book Title: Cell-Extracellular Matrix Interactions in Cancer

  • Editors: Roy Zent, Ambra Pozzi

  • DOI: https://doi.org/10.1007/978-1-4419-0814-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-1-4419-0813-1Published: 14 December 2009

  • Softcover ISBN: 978-1-4899-8112-7Published: 28 November 2014

  • eBook ISBN: 978-1-4419-0814-8Published: 23 January 2010

  • Edition Number: 1

  • Number of Pages: XII, 314

  • Topics: Cancer Research, Cell Biology, Pharmacology/Toxicology

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