Cancer Genetics

Cancer Genome and Tumor Microenvironment

Editors: Thomas-Tikhonenko, Andrei (Ed.)

  • Reviews how tumor microenvironment and progression are “hard-wired” at the genetic level

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-0711-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-4419-0710-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-4614-2524-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.

Reviews

From the reviews:

“This book compiles recent works on genetic alterations that have been associated with carcinogenesis and attempts to present these in the context of the interaction of tumor cells with their microenvironment. The book provides a great deal of information on specific subjects of research, and is very useful as a reference. … The audience includes scientists and physicians involved in basic and translational research.” (Khashayarsha Khazaie, Doody’s Review Service, July, 2010)

“This book amends a space of nowaday cancer bibliography in the area of tumor microenvironment as it provides detailed overview of crucial steps of tumorigenesis. Book consists of 20 chapters that are divided into 4 main parts in addition to introductory editor’s part providing short characteristics of particular chapters and closing one. … The book is very useful for PhD students and for all researchers who intend to be more oriented in advances of molecular oncology. Therefore the book is highly recommended.” (J. Sedlák, Neoplasma, February, 2011)


Table of contents (16 chapters)

  • Hardwiring Tumor Progression

    Thomas-Tikhonenko, Andrei

    Pages 3-8

  • PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition

    Bellacosa, A. (et al.)

    Pages 11-32

  • Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment

    Brady, Donita C. (et al.)

    Pages 67-91

  • RAS Oncogenes and Tumor-Vascular Interface

    Rak, Janusz

    Pages 133-165

  • Myc and Control of Tumor Neovascularization

    Sundaram, Prema (et al.)

    Pages 167-187

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-1-4419-0711-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA
  • ISBN 978-1-4419-0710-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $339.00
price for USA
  • ISBN 978-1-4614-2524-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Cancer Genome and Tumor Microenvironment
Editors
  • Andrei Thomas-Tikhonenko
Series Title
Cancer Genetics
Copyright
2010
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-0711-0
DOI
10.1007/978-1-4419-0711-0
Hardcover ISBN
978-1-4419-0710-3
Softcover ISBN
978-1-4614-2524-3
Edition Number
1
Number of Pages
IX, 480
Number of Illustrations and Tables
29 b/w illustrations, 16 illustrations in colour
Topics