Pharmaceutical Perspectives of Cancer Therapeutics

Editors: Lu, Yi, Mahato, Ram I. (Eds.)

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About this book

Pharmaceutical Perspectives of Cancer Therapeutics presents a comprehensive yet easy-to-follow review of the principles, current progress and state-of-the-art of cancer therapeutics. The complexity of cancer demands an integrated understanding from both cancer biology and pharmaceutical dosage forms and drug delivery in order to warrant a successful therapeutic regimen. This book combines and merges the knowledge from these two aspects. Internationally acclaimed experts with a multi-disciplinary background, including scientists and clinicians from both academia and industries have contributed to this book to bridge the following areas between basic research and clinical application, pharmaceutical drug development processes and regulatory issues, drug design and delivery, laboratory and translational experimentation, marketing and postmarketing surveillance.

Main features of the book:

  • Anticancer drug development and regulatory processes.
  • Strategies to suppress tumor angiogenesis and metastasis, overcome multi-drug resistance in cancer, target telomerase and apoptosis pathways.
  • Therapeutic approaches to employ monoclonal antibody and cancer vaccines.
  • Introduction of new concepts such as cancer stem cells and new technologies such as nanobiotechnology, RNA interference, microRNA, and cancer cell gene profiling.
  • Use of lipids, polymers and peptides for drug delivery and targeting to cancer cells or specific organs.
  • Utilization of bioimaging and HIF-1 knockout animal models in cancer study.
  • Clinical trials designs and principles

About the authors

Yi Lu graduated with B.S. in Biochemistry from Fudan University in Shanghai, China in 1984, and Ph.D. in Biochemistry and Molecular Biology from University of Nebraska Medical Center, Omaha, NE, USA in 1992. He is currently an Associate Professor at the Departments of Pathology, Medicine, and Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. His research interests include tumor angiogenesis and metastasis, gene therapy for prostate cancer and breast cancer, targeted gene expression, and exploration of novel apoptosis-inducing genes. He has more than 50 publications and holds five patents.

Ram I Mahato is a full time Associate Professor in the Department of Pharmaceutical Sciences at the University of Health Science Center Memphis. He was a Research Assistant Professor at the University of Utah Salt Lake City, Senior Scientist at GeneMedicine, Inc., The Woodland, TX, and postdoctoral fellow at the University of Southern California in Los Angeles, Washington University in St Louis and Kyoto University, Japan. He received his B.S. in Pharmaceutics from China Pharmaceutical University in 1989 and PhD in Pharmaceutics and Drug Delivery from the University of Strathclyde in 1992. He is an author or co-author of 79 peer reviewed articles and book chapters. He has also edited/written three books and is a special features editor of Pharmaceutical Research and on the editorial board of the Journal of Drug Targeting, Expert Opinion on Drug Delivery, and Transplantation and Risk Management. His research includes delivery and targeting of small molecules, oligonucleotides, siRNA and genes.

Table of contents (21 chapters)

  • Tumor Microvasculature and Microenvironment: Therapeutic Targets for Inhibition of Tumor Angiogenesis and Metastasis

    Madu, Chikezie O. (et al.)

    Pages 1-47

  • Anticancer Drug Development

    Narang, Ajit S. (et al.)

    Pages 49-92

  • Tumor-Targeted Macromolecular Drug Delivery Based on the Enhanced Permeability and Retention Effect in Solid Tumor

    Seki, Takahiro (et al.)

    Pages 93-120

  • Multidrug Resistance in Solid Tumor and Its Reversal

    Wong, Ho Lun (et al.)

    Pages 121-148

  • Targeting of Apoptosis Signaling Pathways and Their Mediators for Cancer Therapy

    Rishi, Arun K. (et al.)

    Pages 149-188

Buy this book

eBook $259.00
price for USA (gross)
  • ISBN 978-1-4419-0131-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $329.00
price for USA
  • ISBN 978-1-4419-0130-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmaceutical Perspectives of Cancer Therapeutics
Editors
  • Yi Lu
  • Ram I. Mahato
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-1-4419-0131-6
DOI
10.1007/978-1-4419-0131-6
Hardcover ISBN
978-1-4419-0130-9
Edition Number
1
Number of Pages
XVI, 694
Topics