Phagocytosis of Dying Cells

From Molecular Mechanisms to Human Diseases

Editors: Krysko, Dmitri V., Vandenabeele, Peter (Eds.)

  • Is the first book on this subject
  • Is devoted to describing the molecular mechanisms of phagocytosis of dying cells and examining the impact of defective clearance of dying cells on the immune function and development of human diseases
  • Will be of great interest and value for students in medical, biomedical, and biotechnological faculties and for researchers in biotechnological companies and of particular interest to cell biologists, immunologists and clinicians
  • Also gives an overview of the molecular pathways of apoptosis, necrosis, and autophagy as well as of the methods available for studying their clearance
  • Includes 59 illustrations (40 in color) to facilitate easy and clear understanding of what are sometimes quite complex phenomena
  • Contains sufficient cross-referencing and indexing to enable the reader to easily locate the sources or origins of the ideas elaborated in the different chapters
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Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4020-9293-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4020-9292-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-94-017-8299-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning “devouring cells,” was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 “in recognition of their work on immunity.” At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters.

Table of contents (15 chapters)

  • Molecular Pathways of Different Types of Cell Death: Many Roads to Death

    Krysko, Dmitri V. (et al.)

    Pages 3-31

  • Apoptotic, Autophagic and Necrotic Cell Death Types in Pathophysiological Conditions: Morphological and Histological Aspects

    D’Herde, K (et al.)

    Pages 33-62

  • Role of Attraction and Danger Signals in the Uptake of Apoptotic and Necrotic Cells and its Immunological Outcome

    Peter, Christoph (et al.)

    Pages 63-101

  • Molecules Involved in Recognition and Clearance of Apoptotic/Necrotic Cells and Cell Debris

    Napirei, Markus (et al.)

    Pages 103-145

  • Evolutionarily Conserved Pathways Regulating Engulfment of Apoptotic Cells

    Gronski, Matthew A. (et al.)

    Pages 147-162

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4020-9293-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-1-4020-9292-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-94-017-8299-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phagocytosis of Dying Cells
Book Subtitle
From Molecular Mechanisms to Human Diseases
Editors
  • Dmitri V. Krysko
  • Peter Vandenabeele
Copyright
2009
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-9293-0
DOI
10.1007/978-1-4020-9293-0
Hardcover ISBN
978-1-4020-9292-3
Softcover ISBN
978-94-017-8299-9
Edition Number
1
Number of Pages
X, 447
Topics