Handbook on Immunosenescence

basic understanding and clinical applications

Editors: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (Eds.)

  • Comprehensive: covers all aspects of immunosenescence in one volume
  • Offers a bridge in the field between research and clinical applications
  • Useful for anti-aging research and clinical practice
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eBook $529.00
price for USA (gross)
  • ISBN 978-1-4020-9063-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $669.00
price for USA
  • ISBN 978-1-4020-9062-2
  • Free shipping for individuals worldwide
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About this book

“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”

Reviews

From the reviews: “The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections … . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library.” (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)

Table of contents (46 chapters)

  • The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

    Wikby, Anders (et al.)

    Pages 3-28

  • Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

    Lugli, Enrico (et al.)

    Pages 29-62

  • Mouse Models and Genetics of Immunosenescence

    Yu, Qing (et al.)

    Pages 63-85

  • Insect Models of Immunosenescence

    Leips, Jeff

    Pages 87-105

  • Clonal Culture Models of T-cell Senescence

    Pawelec, Graham (et al.)

    Pages 107-115

Buy this book

eBook $529.00
price for USA (gross)
  • ISBN 978-1-4020-9063-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $669.00
price for USA
  • ISBN 978-1-4020-9062-2
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Handbook on Immunosenescence
Book Subtitle
basic understanding and clinical applications
Editors
  • Tamas Fulop
  • Claudio Franceschi
  • Katsuiki Hirokawa
  • Graham Pawelec
Copyright
2009
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-9063-9
DOI
10.1007/978-1-4020-9063-9
Hardcover ISBN
978-1-4020-9062-2
Edition Number
1
Number of Pages
XXXI, 1693
Topics