Cancer Treatment and Research

Targeting Treatment of Soft Tissue Sarcomas

Editors: Verweij, Jaap, Pinedo, H.M. (Eds.)

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About this Textbook

Recent achievements in the development of new techniques and agents for the treatment of cancer in general as well as for soft tissue sarcomas are tremendous. Molecular biology research has changed the landscape considerably and an increasing number of subtypes of soft tissue sarcomas are related to changes in cellular growth factors in the cell signaling pathways. This enables the development of targeted agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the activation constituted by mutations has led to the discovery of an extremely active specific KIT tyrosine kinase inhibitor.

In accordance with the more targeted approach in drug use, the changes in the field of radiation therapy and surgery basically focus on a better targeting of the disease, albeit not yet based on the molecular characteristics. All of these stress the importance of the multidisciplinary approach to the treatment of soft tissue sarcoma that was the focus of previous editions of this book.

Targeting Treatment of Soft Tissue Sarcomas summarizes the recent events in this field, putting the achievements in perspective. Physicians and researchers working in the field of soft tissue sarcomas must be aware of the changes in treatment, the underlying concepts, and of the changes we face in the future.

Reviews

"The management of soft tissue sarcomas remains a difficult challenge. However, significant advances have occurred in our understanding of the important signaling molecules in these diseases. Experts in the field discuss the critical therapeutic targets and relevant treatment strategies for these malignancies."
(Steven T. Rosen, M.D., Series Editor)

Table of contents (10 chapters)

  • Targeted therapy: Ready for prime time?

    Seynaeve, Caroline (et al.)

    Pages 1-15

  • Volume-based radiotherapy targeting in soft tissue sarcoma

    Ward, Iain (et al.)

    Pages 17-42

  • Preoperative therapy for soft tissue sarcoma

    Cormier, Janice N. (et al.)

    Pages 43-63

  • TNF-based isolated limb perfusion: A decade of experience with antivascular therapy in the management of locally advanced extremity soft tissue sarcomas

    Grünhagen, Dirk J (et al.)

    Pages 65-79

  • Pitfalls in pathology of soft tissue sarcomas

    Bovée, Judith V.M.G. (et al.)

    Pages 81-97

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-1-4020-7856-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $125.00
price for USA
  • ISBN 978-1-4020-7808-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $125.00
price for USA
  • ISBN 978-1-4757-7941-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Targeting Treatment of Soft Tissue Sarcomas
Editors
  • Jaap Verweij
  • H.M. Pinedo
Series Title
Cancer Treatment and Research
Series Volume
120
Copyright
2004
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4020-7856-9
DOI
10.1007/b113259
Hardcover ISBN
978-1-4020-7808-8
Softcover ISBN
978-1-4757-7941-7
Series ISSN
0927-3042
Edition Number
1
Number of Pages
VII, 184
Topics