Endocrine Updates

Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

Editors: Beck-Peccoz, Paolo (Ed.)

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About this Textbook

The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still enigmatic mechanism of negative feedback control of thyroid hormones on TSH secretion and the different etiologic mechanisms causing thyroid hormone resistance in patients without mutations in the thyroid hormone receptor ~. The role of the structure of thyroid hormone and TSH receptors in designing agonist or antagonist molecules is extensively debated. Moreover, new forms of congenital or acquired resistance to thyroid hormones are presented.

Reviews

"Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis is a tour-de force by expert authors in the field of thyroid hormone action. Using clinical syndromes of thyroid hormone and TSH resistance, they explore the fundamental mechanisms for thyroid hormone structure-function defects and translate these fascinating molecular observations into an understanding of the pathogenesis of human disease. Endocrinologists, internists, pediatricians and students of the thyroid axis and hormone action will enjoy the depth and breadth of information which has been assembled by the Editor to provide a truly unique cutting edge state of the art."
(Shlomo Melmed, M.D., Series Editor, "Endocrine Updates)

Table of contents (12 chapters)

  • Molecular Basis of Thyroid Hormone Action

    Yen, Paul M.

    Pages 1-11

  • Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models

    Plateroti, Michelina (et al.)

    Pages 13-33

  • Learning from Nature’s Experiments on the Thyroid Hormone Receptor; X-Ray Structures of RTH Mutant Ligand-Binding Domains

    Sandler, Ben H. (et al.)

    Pages 35-56

  • Molecular Pathogenesis of Resistance to Thyroid Hormone

    Chatterjee, V. K. K.

    Pages 57-68

  • Syndromes of Resistance to Thyroid Hormone: Clinical Aspects

    Mannavola, Deborah (et al.)

    Pages 69-88

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4020-7852-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-1-4020-7807-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • ISBN 978-1-4757-1065-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis
Editors
  • Paolo Beck-Peccoz
Series Title
Endocrine Updates
Series Volume
22
Copyright
2004
Publisher
Springer US
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-1-4020-7852-1
DOI
10.1007/978-1-4020-7852-1
Hardcover ISBN
978-1-4020-7807-1
Softcover ISBN
978-1-4757-1065-6
Series ISSN
1566-0729
Edition Number
1
Number of Pages
VIII, 198
Number of Illustrations and Tables
45 b/w illustrations
Topics