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Endocrine Updates

Somatostatin

Editors: Srikant, Coimbatore B. (Ed.)

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About this Textbook

Thirty years have passed since somatostatin was discovered and its hormonal function defined [1,2]. The wide range of anatomical distribution and actions of somatostatin and its receptors stimulated intense scientific and clinical interest, and fostered extensive research into all aspects of its biology including regulation of its gene expression, processing of its precursor, biological and cellular actions relating to regulation cell secretion, motility and proliferation. The development of metabolically stable peptide analogs helped define its usefulness in the treatment of endocrine diseases and cancer. The heterogeneity of somatostatin receptors recognized in 1981 [3] was later shown to result from the existence and variable expression of five distinct subtypes that constitutes two distinct subfamilies with distinguishing pharmacological characteristics [4,5]. The molecular cloning of these receptor subtypes reignited the interest in this field leading to a major increase in our insight into the biology of somatostatin and its receptor subtypes, and has led to the design and development of subtype-selective peptide and non-peptide agonists and antagonists. Significant progress has been made in both basic and clinical research on somatostatin. Noteworthy developments include the role of somatostatin in neuronal patterning, delineation of subtype-selective cytostatic / cytotoxic antiproliferative actions, manipulation of cellular signaling by oligomeric association of somatostatin receptor subtypes amongst themselves or with other G protein-coupled receptors, application of radionuclide-tagged derivatives to localize somatostatin receptor positive tumors and their treatment through targeted delivery of radionuclide or chemotoxin tagged agonists through receptor-mediated endocytosis.

Reviews

"Since the discovery of somatostatin barely 30 years ago, the mechanism of action of this ubiquitous peptide has been rigorously investigated. This volume contains a comprehensive tour de force of advances in molecular, cellular, and physiologic aspects of somatostatin function and action, will be a useful resource for understanding current concepts of this hormone action, and also illuminates future directions for further investigation in this important area of peptide biology."
(Shlomo Melmed, M.D., Series Editor, Endocrine Updates)

Table of contents (19 chapters)

  • Somatostatin Gene Structure and Regulation

    Vallejo, Mario

    Pages 1-16

  • Processing and Intracellular Targeting of Somatostatin

    Mouchantaf, Rania (et al.)

    Pages 17-27

  • Cortistatin- A Novel Member of the Somatostatin Gene Family

    Fabre, Véronique (et al.)

    Pages 29-45

  • Molecular Evolution of Somatostatin Genes

    Tostivint, Hervé (et al.)

    Pages 47-64

  • Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice

    Low, Malcolm J. (et al.)

    Pages 65-80

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-1-4020-8033-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.00
price for USA
  • ISBN 978-1-4020-7799-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $149.00
price for USA
  • ISBN 978-1-4419-5440-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Somatostatin
Editors
  • Coimbatore B. Srikant
Series Title
Endocrine Updates
Series Volume
24
Copyright
2004
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4020-8033-3
DOI
10.1007/b112847
Hardcover ISBN
978-1-4020-7799-9
Softcover ISBN
978-1-4419-5440-4
Series ISSN
1566-0729
Edition Number
1
Number of Pages
XVI, 311
Number of Illustrations and Tables
28 b/w illustrations, 3 illustrations in colour
Topics