Signal Transduction in Cancer

1. Front Matter

   Pages i-viii

   PDF

2. Receptors

   1. Growth, Survival and Migration: The Trk to Cancer

      • Joshua B. Rubin, Rosalind A. Segal

      Pages 1-18

   2. The Role of Growth Factor Signaling in Malignancy

      • Roy S. Herbst, Amir Onn, John Mendelsohn

      Pages 19-72

   3. TGF-β Signaling Alterations in Cancer

      • Yansong Bian, Virginia Kaklamani, Jennifer Reich, Boris Pasche

      Pages 73-94

   4. Notch in Malignancy

      • Douglas W. Ball, Steven D. Leach

      Pages 95-121

3. Intracellular Pathways

   1. cAMP Signaling in Cancer Genesis and Treatment

      • Yoon S. Cho-Chung

      Pages 123-143

   2. PI3K/PTEN/Akt Pathway

      • Juan Paez, William R. Sellers

      Pages 145-167

   3. Wnt Signaling in Human Cancer

      • Patrice J. Morin, Ashani T. Weeraratna

      Pages 169-187

   4. Ras Signaling, Deregulation of Gene Expression and Oncogenesis

      • Aylin S. Ülkü, Channing J. Der

      Pages 189-208

   5. Role of the RB Tumor Suppressor in Cancer

      • Lili Yamasaki

      Pages 209-239

4. Transcription Factors

   1. The Rel/NF-κB/IκB Signal Transduction Pathway and Cancer

      • Thomas D. Gilmore

      Pages 241-265

   2. STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies

      • David A. Frank

      Pages 267-291

   3. Steroid Hormone Receptor Signaling in Cancer

      • Shinta Cheng, Steven P. Balk

      Pages 293-318

5. Cell Death Pathways

   1. Cell Death Signaling in Malignancy

      • Timothy F. Burns, Wafik S. El-Deiry

      Pages 319-343

   2. Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies

      • David K. Perry, Richard N. Kolesnick

      Pages 345-354

6. Back Matter

   Pages 355-357

   PDF

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.
This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Series Editor comments:
"The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

• cell
• cell death
• hormones
• pathogenesis
• tumor

"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research."
(Cancer Forum, 27:3)

• Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA

  David A. Frank

Policies and ethics