Proteins and Cell Regulation

The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

Editors: Mackness, B., Mackness, M., Aviram, M., Paragh, G. (Eds.)

  • Details a unique and novel enzyme whose physiological/pathological function(s) are just starting to be revealed
  • Features up-to-date information by invited speakers at the 2006 International Conference on Paraoxonases
  • Contains chapters by the leading international experts in their field
  • Covers the breadth of current research into the paraoxonases
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eBook $199.00
price for USA (gross)
  • ISBN 978-1-4020-6561-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4020-6560-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-90-481-7670-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates.

Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.

Table of contents (21 chapters)

  • Paraoxonases: An Historical Perspective

    Furlong, C.E.

    Pages 3-31

  • Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form

    Rosenblat, Mira (et al.)

    Pages 35-49

  • Paraoxonase-1 and Cardiovascular Disease

    Mackness, B. (et al.)

    Pages 51-60

  • Oxidative Stress & Antioxidants and PON1 in Health and Disease

    Sozmen, Eser Yildirim (et al.)

    Pages 61-73

  • D-4F Increases Paraoxonase 1 Activity in HDL

    Hough, Greg

    Pages 75-86

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4020-6561-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-1-4020-6560-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-90-481-7670-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism
Editors
  • Bharti Mackness
  • Mike Mackness
  • Michael Aviram
  • György Paragh
Series Title
Proteins and Cell Regulation
Series Volume
6
Copyright
2008
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-6561-3
DOI
10.1007/978-1-4020-6561-3
Hardcover ISBN
978-1-4020-6560-6
Softcover ISBN
978-90-481-7670-0
Edition Number
1
Number of Pages
XV, 325
Topics