Heat Shock Proteins

Heat Shock Proteins in Cancer

Editors: Calderwood, Stuart K., Sherman, Michael Y., Ciocca, Daniel R. (Eds.)

  • First book to comprehensively cover heat shock proteins in cancer -- an area of high interest
  • Detailed discussion of the role of hsp90 in cancer therapy and drug development
  • Heat shock proteins both as targets for chemotherapy and immunotherapy are examined
  • Unique mechanisms for Hsp in cancer such as apoptosis, senescence and a role in NDA repair are discussed
see more benefits

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-6401-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-6400-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7627-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Table of contents (19 chapters)

  • The Hsp90 Chaperone Machinery Acts at Protein Folding Clefts to Regulate Both Signaling Protein Function and Protein Quality Control

    Pratt, William B. (et al.)

    Pages 1-30

  • Implications of Heat Shock Proteins in Carcinogenesis and Cancer Progression

    Ciocca, Daniel R. (et al.)

    Pages 31-52

  • HSF1: An Emerging Factor In Cancer

    Calderwood, Stuart K. (et al.)

    Pages 53-72

  • Anti-apoptotic, Tumorigenic and Metastatic Potential of Hsp27 (HspB1) and αB-crystallin (HspB5): Emerging Targets for the Development of New Anti-Cancer Therapeutic Strategies

    Arrigo, Andre-Patrick

    Pages 73-92

  • Heat Shock Protein-27 (Hsp-27) in Breast Cancers: Regulation of Expression and Function

    Budhram-Mahadeo, Vishwanie S. (et al.)

    Pages 93-130

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-6401-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-6400-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7627-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Heat Shock Proteins in Cancer
Editors
  • Stuart K. Calderwood
  • Michael Y. Sherman
  • Daniel R. Ciocca
Series Title
Heat Shock Proteins
Series Volume
2
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-6401-2
DOI
10.1007/978-1-4020-6401-2
Hardcover ISBN
978-1-4020-6400-5
Softcover ISBN
978-90-481-7627-4
Series ISSN
1877-1246
Edition Number
1
Number of Pages
X, 400
Topics