Nato Science Series II:

Evolving Methods for Macromolecular Crystallography

The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents

Editors: Read, Randy J., Sussman, Joel L. (Eds.)

  • Arises from the renowned Erice Schools on Macromolecular Crystallography
  • Chapters by leading experts in modern methods of macromolecular crystallography
  • Spans the range from detailed practical advice to advanced analytical techniques
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  • ISBN 978-1-4020-6316-9
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Hardcover $289.00
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Softcover $109.00
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  • ISBN 978-1-4020-6315-2
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About this book

This volume comprises papers presented at the 2005 edition of the “Crystallography of Molecular Biology” courses that have been held since 1976 at the Ettore Majorana Centre for Scientific Culture in Erice, Italy. This series of courses is renowned for bringing leaders in the field of macromo- cular crystallography together with highly motivated students, in a beautiful and intimate location that encourages people to interact. The warm and informal atmosphere at these Erice conferences, especially these on cryst- lography, has helped to foster long-term scientific interactions and new int- national friendships that have often lasted for the lifetime of the scientists. The course was financed by NATO as an Advanced Study Institute and by the European Commission as a EuroSummerSchool. The papers span the breadth of material presented in the course, which emphasized the practical aspects of modern macromolecular crystallography and its applications. One must start with crystals: Bergfors showed how to improve initial crystals through seeding, while Byrne discussed the difficult problem of crystallizing membrane proteins. The collection of optimal diffraction data requires both careful preparation of cryo-cooled crystals (Garman) and proper processing of the diffraction images (Leslie). To obtain images of electron density, one needs estimates of the phases of the diffracted spots. Sheldrick presented the background to the sing- wavelength anomalous diffraction (SAD) method, which has been gaining popularity, and McCoy discussed the basis of modern maximum likelihood methods for treating information in experimental phasing.

Reviews

From the reviews:

"The book is a summary of the proceedings on ‘Evolving Methods for Macromolecular Crystallography’ held in 2005. … it is a welcome addition to the crystallographer’s bookshelf with contributions by a number of experts in their field." (Miroslav Papiz, Crystallography Reviews, Vol. 15 (2), 2009)


Table of contents (15 chapters)

  • Succeeding with seeding: some practical advice

    Bergfors, Terese

    Pages 1-10

  • Expression, purification, and crystallisationof membrane proteins

    Byrne, Bernadette

    Pages 11-23

  • Macromolecular cryo-crystallography

    Garman, Elspeth

    Pages 25-40

  • Processing diffraction data with mosflm

    Leslie, Andrew G. W. (et al.)

    Pages 41-51

  • Sad phasing: basic concepts and high-throughput

    Sheldrick, George M.

    Pages 53-65

Buy this book

eBook $84.99
price for USA (gross)
  • ISBN 978-1-4020-6316-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-6314-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $109.00
price for USA
  • ISBN 978-1-4020-6315-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Evolving Methods for Macromolecular Crystallography
Book Subtitle
The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents
Editors
  • Randy J. Read
  • Joel L. Sussman
Series Title
Nato Science Series II:
Series Volume
245
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-6316-9
DOI
10.1007/978-1-4020-6316-9
Hardcover ISBN
978-1-4020-6314-5
Softcover ISBN
978-1-4020-6315-2
Series ISSN
1568-2609
Edition Number
1
Number of Pages
VIII, 192
Topics