Proteases in Biology and Disease

Intramembrane-Cleaving Proteases (I-CLiPs)

Editors: Hooper, Nigel M., Lendeckel, Uwe (Eds.)

  • First book to deal with this emerging group of proteases
  • Comprehensive review of the current state of research on I-CLiPs
  • Contributions by authors recognized as leaders in their fields
  • Easy-to-read descriptive text
  • Latest information concerning the roles that these I-CLiPs play in biology and disease
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eBook $169.00
price for USA (gross)
  • ISBN 978-1-4020-6311-4
  • Digitally watermarked, DRM-free
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4020-6310-7
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $219.00
price for USA
  • ISBN 978-90-481-7604-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.

Table of contents (4 chapters)

  • Signal Peptide Peptidases

    Todd E. Golde, Criag Zwizinski, Andrew Nyborg

    Pages 17-30

  • GXGD-Type Intramembrane Proteases

    Harald Steiner, Christian Haass

    Pages 31-49

  • Rhomboid Intramembrane Serine Proteases

    Sinisa Urban

    Pages 51-77

  • Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae

    Elke Pratje

    Pages 79-88

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-1-4020-6311-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-1-4020-6310-7
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $219.00
price for USA
  • ISBN 978-90-481-7604-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Intramembrane-Cleaving Proteases (I-CLiPs)
Editors
  • Nigel M. Hooper
  • Uwe Lendeckel
Series Title
Proteases in Biology and Disease
Series Volume
6
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-6311-4
DOI
10.1007/978-1-4020-6311-4
Hardcover ISBN
978-1-4020-6310-7
Softcover ISBN
978-90-481-7604-5
Edition Number
1
Number of Pages
IX, 142
Topics