Cancer Metastasis - Biology and Treatment

Metastasis of Prostate Cancer

Editors: Ablin, Richard J., Mason, Malcolm D. (Eds.)

  • Brings together experts from the laboratory and the clinic
  • Highlights the key areas of active, current, translational research
  • Solid resource for physicians and scientists involved in the study of prostate cancer and the progression and metastization of the disease
see more benefits

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-5847-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-5846-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-94-017-8152-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.

Table of contents (16 chapters)

  • Introduction: Metastasis as a Therapeutic Target

    Ablin, Richard J. (et al.)

    Pages 1-3

  • The Natural History of Prostate Cancer

    Penson, David F. (et al.)

    Pages 5-19

  • The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target?

    Maitland, Norman J.

    Pages 21-61

  • Polyunsaturated Fatty Acids and Prostate Cancer Metastasis

    Jiang, Wen G.

    Pages 63-85

  • Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis

    Badawi, Alaa F.

    Pages 87-109

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-5847-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-5846-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-94-017-8152-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Metastasis of Prostate Cancer
Editors
  • Richard J. Ablin
  • Malcolm D. Mason
Series Title
Cancer Metastasis - Biology and Treatment
Series Volume
10
Copyright
2007
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-5847-9
DOI
10.1007/978-1-4020-5847-9
Hardcover ISBN
978-1-4020-5846-2
Softcover ISBN
978-94-017-8152-7
Series ISSN
1568-2102
Edition Number
1
Number of Pages
XIV, 407
Topics