Proteins and Cell Regulation

Smad Signal Transduction

Smads in Proliferation, Differentiation and Disease

Editors: Dijke, Peter, Heldin, Carl-Henrik (Eds.)

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-4709-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-4542-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7145-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

For the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.

Reviews

From the reviews:

"This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. … This is definitely an ‘all-in’ book for those interested in or working on TGFß receptor signal transduction in general and Smad proteins in particular. … it is a must for all of us working in the field of TGFß signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)


Table of contents (4 chapters)

  • Trafficking of Serine/Threonine Kinase Receptors and Smad Activation

    Christine Le Roy, Rohit Bose, Jeffrey L. Wrana

    Pages 177-191

  • Structural Insights into Smad Function and Specificity

    Yigong Shi

    Pages 215-233

  • Interplays Between The Smad and Map Kinase Signaling Pathways

    Delphine Javelaud, Alain Mauviel

    Pages 317-334

  • Gene Expression Signatures of TGF-β/Smad-Induced Responses

    Erwin P. Böttinger, Wenjun Ju

    Pages 335-360

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-4709-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-4542-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7145-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Smad Signal Transduction
Book Subtitle
Smads in Proliferation, Differentiation and Disease
Editors
  • Peter Dijke
  • Carl-Henrik Heldin
Series Title
Proteins and Cell Regulation
Series Volume
5
Copyright
2006
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-4709-1
DOI
10.1007/1-4020-4709-6
Hardcover ISBN
978-1-4020-4542-4
Softcover ISBN
978-90-481-7145-3
Edition Number
1
Number of Pages
XIV, 472
Topics