Proteins and Cell Regulation

RAS Family GTPases

Editors: Der, Channing (Ed.)

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-4708-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-4328-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7110-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Since 1982, Ras proteins have been the subject of intense research investigation by the

biomedical research community. The wide interest in Ras has been stimulated for

three key reasons.

First, their frequent mutational activation in human cancers establishes Ras proteins

as important mediators of oncogenesis and targets for anti-cancer drug discovery.

Second, Ras proteins act as signalling nodes activated by diverse extracellular

stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling

networks.

Third, Ras proteins are founding members of a large superfamily of Ras-related small

GTPases. Over 150 Ras-related small GTPases are found in the human genome, with

orthologs found in all vertebrate species and invertebrates.

This book features chapters by leading investigators in the field that highlight the

current state-of-the art in Ras biochemistry, structure and biology.

This book is an excellent reference for students in the biomedical sciences and for

investigators in the field.

Table of contents (15 chapters)

  • Ras Stories: The State of the Art

    Roberts, Patrick J. (et al.)

    Pages 1-14

  • Ras-Gefs and Ras Gaps

    Rojas, Jose M. (et al.)

    Pages 15-43

  • Structural Principles of Ras Interaction with Regulators and Effectors

    Fiegen, Dennis (et al.)

    Pages 45-66

  • RAS and the RAF/MEK/ERK Cascade

    Morrison, Deborah K. (et al.)

    Pages 67-93

  • Noncanonical Effector Targets Of Oncogenic Ras Proteins

    Boettner, Benjamin (et al.)

    Pages 95-120

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4020-4708-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-1-4020-4328-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-90-481-7110-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
RAS Family GTPases
Editors
  • Channing Der
Series Title
Proteins and Cell Regulation
Series Volume
4
Copyright
2006
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-4708-4
DOI
10.1007/1-4020-4708-8
Hardcover ISBN
978-1-4020-4328-4
Softcover ISBN
978-90-481-7110-1
Edition Number
1
Number of Pages
XI, 396
Topics