Georgia Genetics Review

Mutagenesis of the Mouse Genome

Editors: Justice, Monica, Bedell, Mary (Eds.)

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About this book

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesis, for its biological similarities to the human will permit key discoveries. Mutagenesis of the Mouse Genome focuses on articles relevant to mouse chemical mutagenesis, and is dedicated to the memory of the mutagenesis pioneer, William L. Russell. Monica Justice provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. With special articles by Jean-Louis Guenet describing the history and development of mouse chemical mutagenesis, Liane Russell analyzing decades of data on DNA damage after chemical treatment, Steven Barthold describing how environment can affect mouse phenotypes, Miriam Meisler summarizing the power of allelic series, Molly Bogue describing the variation in mouse inbred strains, and Mark Strivens and Janan Eppig showing how informatics tools can aid in functional analysis, this book is designed to be a handbook and reference guide for mouse genetics in the post-genome era.

Reviews

From the reviews:

"Mutagenesis of the Mouse Genome is a collection of papers originally presented at the Second Georgia Genetics Symposium in 2002 and printed in a special issue of Genetica in 2004. … this volume collects in one place much information that will prove valuable to current and prospective users of the wealth of mice produced by chemical mutagenesis. … this book provides a strong introduction to the origins, acquisition and use of mutagenized mice." (Elissa J. Chesler, Genes, Brain and Behaviour, Vol. 5, 2006)


Table of contents (10 chapters)

  • From the Atomic Age to The Genome Project

    Justice, Monica J.

    Pages 3-7

  • Chemical mutagenesis of the mouse genome: an overview

    Guénet, Jean-Louis

    Pages 9-24

  • Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse

    Russell, Liane B.

    Pages 25-36

  • Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions

    Meisler, Miriam H. (et al.)

    Pages 37-45

  • Towards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disorders

    Rastan, Sohaila (et al.)

    Pages 47-49

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4020-5057-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-1-4020-2875-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-94-017-5104-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mutagenesis of the Mouse Genome
Editors
  • Monica Justice
  • Mary Bedell
Series Title
Georgia Genetics Review
Series Volume
2
Copyright
2004
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-1-4020-5057-2
DOI
10.1007/978-1-4020-5057-2
Hardcover ISBN
978-1-4020-2875-5
Softcover ISBN
978-94-017-5104-9
Edition Number
1
Number of Pages
VI, 98
Additional Information
Reprinted from GENETICA, 122:1, 2004
Topics