Mutagenesis of the Mouse Genome

1. Front Matter

   Pages i-vii

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2. From the Atomic Age to The Genome Project

   • Monica J. Justice

   Pages 3-7

3. Chemical mutagenesis of the mouse genome: an overview

   • Jean-Louis Guénet

   Pages 9-24

4. Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse

   • Liane B. Russell

   Pages 25-36

5. Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions

   • Miriam H. Meisler, Nicholas W. Plummer, Daniel L. Burgess, David A. Buchner, Leslie K. Sprunger

   Pages 37-45

6. Towards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disorders

   • Sohaila Rastan, Tertius Hough, Amy Kierman, Rachel Hardisty, Alexandra Erven, Ian C. Gray et al.

   Pages 47-49

7. Implementing large-scale ENU mutagenesis screens in North America

   • Amander T. Clark, Daniel Goldowitz, Joseph S. Takahashi, Martha Hotz Vitaterna, Sandra M. Siepka, Luanne L. Peters et al.

   Pages 51-64

8. Genetic mapping and ENU mutagenesis

   • David R. Beier, Bruce J. Herron

   Pages 65-69

9. The Mouse Phenome Project

   • Molly A. Bogue, Stephen C. Grubb

   Pages 71-74

10. Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes

    • Stephen W. Barthold

    Pages 75-88

11. Visualizing the laboratory mouse: capturing phenotype information

    • Mark Strivens, Janan T. Eppig

    Pages 89-97

The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

From the reviews:

"Mutagenesis of the Mouse Genome is a collection of papers originally presented at the Second Georgia Genetics Symposium in 2002 and printed in a special issue of Genetica in 2004. … this volume collects in one place much information that will prove valuable to current and prospective users of the wealth of mice produced by chemical mutagenesis. … this book provides a strong introduction to the origins, acquisition and use of mutagenized mice." (Elissa J. Chesler, Genes, Brain and Behaviour, Vol. 5, 2006)

• Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA

  Monica J. Justice

Policies and ethics