The Role of Aging in Atherosclerosis

The Sequestration Hypothesis

Authors: Tracy, R.E.

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About this book

The cover of this book summarizes the central features of the sequestration hypothesis: Commonplace appearances seen in human coronary artery, fat stained in paraffin seetions by a new technique explained in Chapter Eleven, are arranged to suggest pathways of evolution toward atheroma. The hypothesis formulated and defended in the pages ofthis book is this: Fibroplasia progresses upward in column "a" from "la" to "3a" as a characteristic feature of aging. This starts sooner and progresses faster in men than in wornen. Numbers ofSMC's remain essentially constant so that fibroplasia per SMC steadily increases. The rise upward conveys an increasing propensity to sequester atherogenic lipids, causing transition rightward into column "b". Sequestered extracellular lipid then attracts fatty streak elements, especially foam cells and lyrnphocytes, to propel the arterial site rightward into column "c". Frame "lc" corresponds to the AHA Lesions Committee classification type IIb, the progression resistant fatty streak arising directly without prior lipid sequestration; this can progress to atheroma, but slowly after much delay, although extreme provocation can accelerate the process. Such progression is rightward toward atherorna with thin cap, not upward toward fibroplastic thickening. Frame "2c" corresponds to the AHA classification, type Ha, progression prone fatty streaks. These readily evolve into atheroma, again by horizontal progression.

Table of contents (26 chapters)

  • Introducing the Sequestration Hypothesis

    Tracy, Richard E.

    Pages 1-10

  • The Sampling Theory of Fibroplastic Arteriosclerosis

    Tracy, Richard E.

    Pages 11-17

  • Intrusion of Atheroma into the Most Fibrotically Thickened Intimal Sites

    Tracy, Richard E.

    Pages 19-27

  • Conditions for Intrusion Atheroma in Coronary Artery

    Tracy, Richard E.

    Pages 29-36

  • The Size of the SMC Realm Assessed with the Help of Sampling Theory

    Tracy, Richard E.

    Pages 37-49

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-94-017-0263-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-1-4020-1223-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-90-481-6265-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Role of Aging in Atherosclerosis
Book Subtitle
The Sequestration Hypothesis
Authors
Copyright
2003
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-017-0263-8
DOI
10.1007/978-94-017-0263-8
Hardcover ISBN
978-1-4020-1223-5
Softcover ISBN
978-90-481-6265-9
Edition Number
1
Number of Pages
X, 273
Topics