Fundamental Fault in Hypertension

1. Front Matter

   Pages I-XII

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2. The Preamble

   1. Front Matter

      Pages 1-1

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   2. The Long Slow Road to Progress: A Lesson in Humility

      • Irvine H. Page

      Pages 3-18

   3. Sir George Pickering’s Views on Hypertension

      • Thomas G. Pickering

      Pages 19-23

   4. Facts, Interpretations and Extrapolations on the Mechanisms that Cause Arterial Hypertension

      • Juan Carlos Fasciolo

      Pages 25-34

   5. The Infinite Gain Principle for Arterial Pressure Control by the Kidney-Volume-Pressure System

      • Arthur C. Guyton, Thomas E. Lohmeier, John E. Hall, Manis J. Smith, Philip R. Kastner

      Pages 35-61

   6. Hypertension Research: A Viewpoint

      • W. H. Birkenhäger, P. W. De Leeuw

      Pages 62-65

3. How Important is the Salt Intake?

   1. Front Matter

      Pages 67-67

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   2. Deterinants of Blood Pressure in Populations

      • Lot B. Page

      Pages 69-82

4. The Central Role of the Kidney

   1. Front Matter

      Pages 83-83

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   2. The Mechanism of Sodium-Dependent Low Renin Hypertension

      • F. J. Haddy, M. B. Pamnani, D. L. Clough

      Pages 85-104

   3. Mill’s Disease Amongst Medical Specialists in Hypertension

      • P. Mason, D. G. Beevers, C. Beretta-Piccoli, J. J. Brown, A. M. M. Cumming, D. L. Davies et al.

      Pages 105-116

5. A Defect in Cell Membrane Permeability

   1. Front Matter

      Pages 117-117

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   2. Cell Membrane Permeability and Hypertension

      • David F. Bohr

      Pages 119-132

   3. Is Biomembrane Abnormality a Pathogenic Factor or a Genetic Marker of Hypertensive Diseases?

      • Yukio Yamori, Yasuo Nara, Hiroshi Imafuku

      Pages 133-143

6. The Antihypertensive Hormones of the Kidney

   1. Front Matter

      Pages 145-145

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   2. Hypertension Induced by JG-Like Cells Grown in Tissue Culture

      • E. E. Muirhead, J. A. Pitcock, W. A. Rightsel, P. S. Brown, M. F. Hall, B. Brooks

      Pages 147-157

   3. The Glandular Kallikrein-Kinin System in Hypertension

      • Oscar A. Carretero, Alfonso G. Scicli

      Pages 158-174

7. The Role of the Central Nervous System: Mediation or Initiation?

   1. Front Matter

      Pages 175-175

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   2. The Mechanism of Hypertension — A Personal View

      • Austin E. Doyle

      Pages 177-189

The fundamental fault in hypertension is unknown. Calling it a fundamental fault, indeed, tacitly begs the question: Is there one fundamental fault, or are there several that are interlinked or interdependent? A simple yes or no answer cannot be offered. This volume is not designed to survey the up-to-date recent advances in research on hypertension, nor intended to provide provisional an­ swers to the so many unknowns in this topic. It is, in fact, an attempt to articulate questions that are worth asking, given the license of an unhibited, albeit disci­ plined, inquiry. The range of expression varies from dogmatic opinion to a declared speculation. Is the primary abnormality an excessive sodium and reduced potassium intake over generations? Or is it hormonal excess, deficiency, imbalance or altered synthesis of abnormal forms? Does the nervous system playa role of active initiation or only of passive maintenance in the genesis of hypertension? Is the heart only a pump acting in concert with the happenings to the vasculature trying to provide adequate flow in the face of vasconstriction induced by neural or humoral factors, or does it sometimes become the culprit by pumping blood flow in excess of demand and thus initiating hypertrophic changes in blood vessels, or by assuming the role of an endocrine organ and being the source of a hormone with influence on cellular transport of sodium and on vasomotor tone? Is an elusive and mysterious fault in the kidney, the primary basis of all of the above

• arterial pressure
• blood pressure
• heart
• hemodynamics
• hypertension

• Division of Hypertension, Department of Medicine, UCLA, Sepulveda, USA

  Mohinder P. Sambhi

• San Fernando Valley Medical Program, Veterans Administration Medical Center, Sepulveda, USA

  Mohinder P. Sambhi

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