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Introduction to Proteomics

Tools for the New Biology

  • Book
  • © 2002
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Overview

Authors:
  1. Daniel C. Liebler

    1. College of Pharmacy, The University of Arizona, Tucson, USA

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    You can also search for this author in PubMed   Google Scholar

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
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  2. Proteomics and the Proteome

    1. Front Matter

      Pages 1-1
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    2. Proteomics and the New Biology

      • Daniel C. Liebler
      Pages 3-13
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    3. The Proteome

      • Daniel C. Liebler
      Pages 15-24
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  3. Tools of Proteomics

    1. Front Matter

      Pages 25-25
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    2. Overview of Analytical Proteomics

      • Daniel C. Liebler
      Pages 27-29
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    3. Analytical Protein and Peptide Separations

      • Daniel C. Liebler
      Pages 31-48
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    4. Protein Digestion Techniques

      • Daniel C. Liebler
      Pages 49-54
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    5. Mass Spectrometers for Protein and Peptide Analysis

      • Daniel C. Liebler
      Pages 55-76
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    6. Protein Identification by Peptide Mass Fingerprinting

      • Daniel C. Liebler
      Pages 77-87
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    7. Peptide Sequence Analysis by Tandem Mass Spectrometry

      • Daniel C. Liebler
      Pages 89-98
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    8. Protein Identification with Tandem Mass Spectrometry Data

      • Daniel C. Liebler
      Pages 99-108
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    9. SALSA: An Algorithm for Mining Specific Features of Tandem MS Data

      • Daniel C. Liebler
      Pages 109-122
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  4. Applications of Proteomics

    1. Front Matter

      Pages 123-123
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    2. Mining Proteomes

      • Daniel C. Liebler
      Pages 125-135
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    3. Protein Expression Profiling

      • Daniel C. Liebler
      Pages 137-149
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    4. Identifying Protein-Protein Interactions and Protein Complexes

      • Daniel C. Liebler
      Pages 151-165
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    5. Mapping Protein Modifications

      • Daniel C. Liebler
      Pages 167-184
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    6. New Directions in Proteomics

      • Daniel C. Liebler
      Pages 185-193
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  5. Back Matter

    Pages 195-198
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Keywords

About this book

Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Reviews

"Professor Daniel Liebler presents a tutorial on mass spectrometry and its use in proteomics. The basics of mass spectrometers and ionization techniques are described, which is important to ascertain what type of mass spectrometer is most particular for a particular study. The ability to use mass spectrometry data to search databases is an important advance for the non-specialist, because it no longer requires the development of the skills to interpret mass spectra. A basic understanding of the fundamental of the search algorithms and their limitations is described in the book. Finally, applications of mass spectrometry to proteomics are described. This book provides and excellent introduction and overview of proteomics for the graduate student of for any biologist interested in understanding the basics of this rapidly evolving area."-From the foreword by John R. Yates, III

"...a tutorial of mass spectrometry for the biological sciences in general and more specifically for the field of proteomics,...Although designated as a book for beginners, it will almost certainly find a wider audience. In particular, both academics and researchers working in associated fields with a need to hone their knowledge skills will find much to interest them in this well written book." - Chromatographia

"...an excellent overview of this field in an easy-to-read, succcinct format." - Expert Reviews in Proteomics

"...there is a wonderful description of mass spectrometry of peptides, both simple, accurate, up-to-date and very pleasant to read....This book can be recommended for people needing an update in mass spectrometry in proteomics..." - Proteomics

Authors and Affiliations

  • College of Pharmacy, The University of Arizona, Tucson, USA

    Daniel C. Liebler

Bibliographic Information

  • Book Title: Introduction to Proteomics

  • Book Subtitle: Tools for the New Biology

  • Authors: Daniel C. Liebler

  • DOI: https://doi.org/10.1007/978-1-59259-130-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-89603-991-9Published: 04 December 2001

  • Softcover ISBN: 978-0-89603-992-6Published: 04 December 2001

  • eBook ISBN: 978-1-59259-130-5Published: 04 December 2001

  • Edition Number: 1

  • Number of Pages: IX, 198

  • Number of Illustrations: 29 b/w illustrations, 2 illustrations in colour

  • Topics: Pharmacology/Toxicology

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