Methods in Molecular Biology

Tumor Suppressor Genes

Volume 2: Regulation, Function, and Medicinal Applications

Editors: El-Deiry, Wafik S. (Ed.)

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About this book

Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics
Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.

Reviews

"The book will prove a great help to everybody who would like to enter the field of experimental and or clinical research. Those who are interested in basic understanding microbiology of cancer will enjoy this as well." -Neoplasma

Table of contents (39 chapters)

  • Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins

    Marassi, Francesca M.

    Pages 3-15

  • Generation and Application of Phospho-specific Antibodies for p53 and pRB

    Taya, Yoichi (et al.)

    Pages 17-26

  • Stability and Ubiquitination of the Tumor Suppressor Protein p53

    Jardine, Lesley J. (et al.)

    Pages 27-38

  • Role of Tumor Suppressors in DNA Damage Response

    Zhou, Bin-Bing S. (et al.)

    Pages 39-50

  • In Situ Hybridization in Cancer and Normal Tissue

    Kadkol, Shrihari (et al.)

    Pages 51-72

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-59259-329-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-0-89603-987-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA
  • ISBN 978-1-4899-3914-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Suppressor Genes
Book Subtitle
Volume 2: Regulation, Function, and Medicinal Applications
Editors
  • Wafik S. El-Deiry
Series Title
Methods in Molecular Biology
Series Volume
223
Copyright
2003
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-329-3
DOI
10.1385/1592593291
Hardcover ISBN
978-0-89603-987-2
Softcover ISBN
978-1-4899-3914-2
Series ISSN
1064-3745
Edition Number
1
Number of Pages
XIX, 657
Topics