Contemporary Neuroscience

Pathogenesis of Neurodegenerative Disorders

Editors: Mattson, Mark P. (Ed.)

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About this book

Recent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those factors that are critical to the facilitation or suppression of these neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for many clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondrial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy.
Pioneering and richly insightful, Pathogenesis of Neurodegenerative Disorders offers a critical and integrative summary of the cutting-edge research findings that illuminate the common genetic, cellular, and molecular bases of many neurological disorders today that promise powerful new preventive and treatment approaches in future.

Reviews

"...a timely collection of 12 papers authored by 26 experts...mechanisms combined with specific molecular genetic and environmental factors are responsible for the development of the diseases that are covered in a concise...manner in subsequent chapters...The chapter on "Trinucleotide Repeat Disorders" provides fascinating reading...The 12 chapters are balanced in length, are all well referenced, and provide a state of the art summary for those who are only tangentially involved in studying these disorders or treating patients suffering from any of them. On the other hand, for those whose main interest lies in research related to any of these diseases, it is a refreshing, well-written, and well-edited overview of a field that evolves and changes at unprecedented speed....With the help of well-known experts in the relevant fields, several basic pieces of the puzzle are provided that with the appropriate intellectual efforts can be sewn together. The result is the emergence of an overall view, the "Big Picture."...the overall value of the book is undeniable, and it is beyond doubt that it will serve as a major reference source for neurologists, neuropathologists, and residents training in the respective fields." - Modern Pathology

"A wide range of conditions and illnesses are covered, including ALS, muscular dystrophy, Parkinson's, Huntington's, Alzheimer's, Down's, stroke, and spinal cord trauma. Whole articles are devoted to neurogenetic mechanisms, oxidative processes, excitotoxicity, and apoptosis. From the viewpoint of a general clinical neurologist, the best feature of this book is that it is, for the most part, an understandable summary and update of the neuroscience that was not yet discovered a few years ago. The illustrations are of good quality...This book is good for a clinician because it broadens one's horizons and gives the clinician a better ability to help patients understand their problems. It would be good for a researcher or a graduate student because it summarizes what is being done in many fields." -Doody's Health Sciences Book Review Journal

"This handy pocket guide will be useful for many residents and clinicians, especially in those specialties that treat Alzheimer's disease. It is a worthy addition to departmental and hospital libraries and, predictably, will be used quite frequently." - The Canadian Journal of Neurological Sciences

Table of contents (12 chapters)

  • Mechanisms of Neuronal Apoptosis and Excitotoxicity

    Mattson, Mark P.

    Pages 1-20

  • Oxidative Alterations in Neurodegenerative Diseases

    Markesbery, William R. (et al.)

    Pages 21-51

  • Parkinson’s Disease

    Silva, M. T. (et al.)

    Pages 53-79

  • Scope of Trinucleotide Repeat Disorders

    Tsuji, Shoji

    Pages 81-92

  • Mechanisms of Neuronal Death in Huntington’s Disease

    Koliatsos, Vassilis E. (et al.)

    Pages 93-111

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-59259-106-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-89603-838-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-61737-215-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pathogenesis of Neurodegenerative Disorders
Editors
  • Mark P. Mattson
Series Title
Contemporary Neuroscience
Copyright
2001
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-106-0
DOI
10.1007/978-1-59259-106-0
Hardcover ISBN
978-0-89603-838-7
Softcover ISBN
978-1-61737-215-5
Edition Number
1
Number of Pages
X, 294
Number of Illustrations and Tables
27 b/w illustrations
Topics