Methods in Molecular Medicine

Angiotensin Protocols

Editors: Wang, Donna H. (Ed.)

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About this book

The renin-angiotensin system has been in the spotlight for more than 100 years because of its vital role in blood pressure regulation, ion and fluid homeostasis, and tissue growth and remodeling. Recent advances in molecular genetic techniques have established that the renin-angiotensin system may well hold the key to the pathogenesis of hypertension, congestive heart failure, chronic renal failure, and stroke. In Angiotensin Protocols, Donna Wang and a panel of hands-on experts describe in step-by-step detail all the major molecular, biochemical, and functional techniques now used in probing this powerful system. These range from the use of embryonic gene targeting to create mutant strains, to the functional investigation of components of the renin-angiotensin system. Following the successful pattern of the Methods in Molecular Biology™ series, each method is crafted for experimental success with detailed instructions, perceptive notes highlighting the most critical steps, and helpful tips on pitfalls to avoid.
Comprehensive and highly practical, Angiotensin Protocols translates expert knowledge into readily reproducible methods that enable all biomedical investigators successfully to explore the role of angiotensin in health and disease today.

Reviews

"This is an advanced treatise on the renin-angiotensin system (RAS) and its regulation of the cardiovascular, renal, and neural relationships in health and disease. The introduction is ample to move the biological scientist reader up to adequacy to comprehend a complex patient example. ...The purpose shows a goal along with suitable objectives to move traditional medicine into utilization of the amazing explosion of modern biological techniques in RAS applications. It does so with a compilation of experts that foster a clearer picture of the modem RAS field. These are indeed worthy objectives, that surpass what individual papers and review articles can accomplish. Indeed it is needed and it serves as a tremendous thinking stimulator....The introduction by John E. Hall sets the tone and makes this book happen. The genetic manipulation of the RAS by Sigmund and Stec keeps the happening alive. the quantification of angiotensin II receptors by Wu, Yao and Wang is an outstanding peace of work. The cyclic AMP and GMP by Ji was helpful as was the NO from assay work of Thorup and Moore. The closing article on cerebral circulation by Lombard carries the exciting nature of the book to the interested student."-Doody's Health Sciences Book Review Journal

"This book with great attention to the recent developments in molecular genetic, biochemical and fysiological techniques can be recommended to all researchers involved in the fundemental research of the RAS at the cellular level." - Acta Cardiologica

Table of contents (34 chapters)

  • Historical Perspective of the Renin –Angiotensin System

    Hall, John E.

    Pages 3-21

  • Three Angiotensin Paradigms in One Patient

    Laffer, Cheryl L. (et al.)

    Pages 23-37

  • Production and Use of Chimeric Mice

    Takaya, Junji (et al.)

    Pages 41-52

  • Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase

    Sigmund, Curt D. (et al.)

    Pages 53-65

  • Systemic Delivery of aTransgene in Intact Animals by a Retroviral Vector

    Katovich, Michael J. (et al.)

    Pages 67-81

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-1-59259-087-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-0-89603-763-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-61737-176-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Angiotensin Protocols
Editors
  • Donna H. Wang
Series Title
Methods in Molecular Medicine
Series Volume
51
Copyright
2001
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-087-2
DOI
10.1385/159259087X
Hardcover ISBN
978-0-89603-763-2
Softcover ISBN
978-1-61737-176-9
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XIV, 530
Topics