Methods in Molecular Medicine

Alzheimer's Disease

Methods and Protocols

Editors: Hooper, Nigel M. (Ed.)

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Hardcover $179.00
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Softcover $179.00
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About this book

With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy.
Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today‚s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge.

Reviews

"...this volume contains well-written chapters containing factual insights and useful clarifications. An example is David Allsop's introduction of the field through the orthodox views of the amyloid cascade hypothesis that in the exposition of others is often quite simplistic, but here is presented with complexity and wisdom deserving of serious consideration....they are provided in a format that invites the reader to undertake studies and examine the underpinnings of the subject beyond that found in the primary publications and not covered in such a practical manner in other reviews."- Journal of Molecular Neuroscience

Table of contents (27 chapters)

  • Introduction to Alzheimer's Disease

    Allsop, David

    Pages 1-21

  • The Genetics of Alzheimer's Disease

    Brindle, Nick (et al.)

    Pages 23-43

  • Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer's Disease

    Knopman, David S.

    Pages 45-61

  • Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPPα)

    Barger, Steven W.

    Pages 63-78

  • Quantifying Aβ1–40 and Aβ1–42 Using Sandwich-ELISA

    Skovronsky, Daniel M. (et al.)

    Pages 79-89

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-59259-195-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-0-89603-737-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-61737-161-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Alzheimer's Disease
Book Subtitle
Methods and Protocols
Editors
  • Nigel M. Hooper
Series Title
Methods in Molecular Medicine
Series Volume
32
Copyright
2000
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-59259-195-4
DOI
10.1385/1592591957
Hardcover ISBN
978-0-89603-737-3
Softcover ISBN
978-1-61737-161-5
Series ISSN
1543-1894
Edition Number
1
Number of Pages
XIV, 408
Topics