Contemporary Immunology

Therapeutic Interventions in the Complement System

Editors: Lambris, John D., Holers, V. Michael (Eds.)

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  • ISBN 978-1-59259-017-9
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About this book

Although the complement system is a vital part of the body's defenses against bacteria, its inappropriate activation produces the cell damage found in a wide variety of illnesses, ranging from hemolytic anemia to multiple sclerosis. In Therapeutic Interventions in the Complement System, a team of expert investigators and researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, detailing the activation pathways and complement receptors. Informative animal models are thoroughly discussed, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. Also discussed are analytical issues concerning the sensitivity and specificity of the important new ELISA assays for measuring complement. Throughout, the emphasis is on the pros and cons of the use of recombinant complement inhibitors as therapeutics in specific diseases.
Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for clinical researchers and biotechnologists the powerful drug discovery and development strategies that are producing the novel complement inhibitors today emerging for the treatment of a wide variety of clinically important diseases.

Table of contents (10 chapters)

  • Complement as a Regulatory and Effector Pathway in Human Diseases

    Holers, V. Michael

    Pages 1-32

  • The Regulation of C1 Activation and Its Role in Disease

    Hack, C. Erik

    Pages 33-56

  • Inhibition of Complement Serine Proteases as a Therapeutic Strategy

    Narayana, Sthanam V. L. (et al.)

    Pages 57-74

  • Complement Inhibitors Targeting C3, C4, and C5

    Sahu, Arvind (et al.)

    Pages 75-112

  • Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation

    Wetsel, Rick A. (et al.)

    Pages 113-153

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-59259-017-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.00
price for USA
  • ISBN 978-0-89603-587-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-4684-9612-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Therapeutic Interventions in the Complement System
Editors
  • John D. Lambris
  • V. Michael Holers
Series Title
Contemporary Immunology
Copyright
2000
Publisher
Humana Press
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-59259-017-9
DOI
10.1007/978-1-59259-017-9
Hardcover ISBN
978-0-89603-587-4
Softcover ISBN
978-1-4684-9612-3
Edition Number
1
Number of Pages
X, 260
Topics