Osteoporosis

1. Front Matter

   Pages i-xi

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2. Skeletal Physiology and its Relevance to Osteoporosis

   1. Front Matter

      Pages 1-1

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   2. The Cellular and Biochemical Aspects of Bone Remodeling

      • Julie Glowacki

      Pages 3-15

   3. The Role of Calcium, Phosphorus, and Macronutrients in the Maintenance of Skeletal health

      • John J. B. Anderson

      Pages 17-27

   4. Vitamin D in Health and Prevention of Metabolic Bone Disease

      • Michael F. Holick

      Pages 29-43

3. The Pathophysiology of Osteoporosis

   1. Front Matter

      Pages 45-45

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   2. The Pathophysiology of Osteoporosis

      • Cathy R. Kessenich, Clifford J. Rosen

      Pages 47-63

   3. The Epidemiology of Osteoporosis

      • Michael Kleerekoper

      Pages 65-68

   4. Psychosocial Aspects of Osteoporosis

      • Betsy Love McClung, Judith H. Overdorf

      Pages 69-75

4. The Diagnosis of Osteoporosis

   1. Front Matter

      Pages 77-77

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   2. What Is an Osteoporotic Fracture?

      • Richard Wasnich

      Pages 79-88

   3. Bone Densitometry Techniques in Modern Medicine

      • Sydney Lou Bonnick

      Pages 89-111

   4. Clinical Interpretation and Utility of Bone Densitometry

      • Paul D. Miller

      Pages 113-119

   5. Quantitative Ultrasound

      • Daniel T. Baran

      Pages 121-128

   6. Biochemical Markers of Bone Turnover

      • Clifford J. Rosen

      Pages 129-141

5. The Treatment of Osteoporosis

   1. Front Matter

      Pages 143-143

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   2. An Introduction to Clinical Decision Making in Osteoporosis

      • Gordon H. Guyatt

      Pages 145-149

   3. Calcium as a Primary Treatment and Prevention Modality for Osteoporosis

      • Robert Marcus

      Pages 151-158

   4. Use of Estrogen for Prevention and Treatment of Osteoporosis

      • Robert Marcus

      Pages 159-172

   5. Drug Therapy

      • John L. Stock

      Pages 173-187

LA WRENCE G. RAISZ, MD Division of Endocrinology and Metabolism, University of Connecticut Health Center. Farmington. CT The rapid transfer of new knowledge concerning the pathogenesis, diagnosis, preven­ tion, and treatment of disease into clinical practice has always been a major challenge in medicine. This challenge is particularly difficult to meet in osteoporosis, not only because has been so much new knowledge generated in recent years, but also because this there disorder has not caught the attention of many practicing physicians. The goal of this volume is to help primary care physicians develop a better understanding of osteoporosis and a more effective approach to diagnosis, prevention, and treatment. As primary care physicians become more and more responsible for the maintenance of health and the prevention of disease, osteoporosis must become one of their important concerns. The magnitude of the problem of osteoporosis has been widely publicized. Within the next 30 years, the cost of hip fractures alone is expected to exceed $40 billion a year in the United States and will be a major cause ofincreased mortality. In addition, vertebral crush fractures will cripple more and more of our elderly population, both men and women. This enormous toll is not inevitable. Current methods of identifying individuals at risk and applying preventive programs could reduce the incidence offractures by 50% or more. This should be the minimum goal of clinicians.

• Vitamin D
• bone
• fracture
• glucocorticoid
• osteoporosis
• pathophysiology
• physiology
• prevention
• primary care

...give[s] readers a complete 'briefing' on osteoporosis. The last section provides a unique perspective on clinical management in the form of case presentations.-Journal of Musculoskeletal Medicine

• Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, USA

  Clifford J. Rosen

Policies and ethics