Alzheimer’s Dementia

1. Front Matter

   Pages i-xx

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2. Legal and Science Background

   1. Front Matter

      Pages N1-N1

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   2. Current Frontiers in Research on Alzheimer’s Disease

      • Robert Katzman

      Pages 1-11

   3. Current Regulations for the Protection of Human Subjects

      • Charles R. McCarthy

      Pages 13-18

   4. Clinical Symptoms Accompanying Progressive Cognitive Decline and Alzheimer’s Disease

      • Barry Reisberg, Betty Gordon, Martin McCarthy, Steven H. Ferris

      Pages 19-39

   5. The Physician—Researcher

      • Robert J. Levine

      Pages 41-50

3. Personal Perspectives

   1. Front Matter

      Pages N3-N3

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   2. Impact of Alzheimer’s Disease and the Role of the Patient’s Family

      • Hilda Pridgeon

      Pages 51-58

   3. Advocacy for Persons with Senile Dementia

      • Nancy C. Paschall

      Pages 59-69

   4. Ethical Issues in the Care of the Patient Involved in Alzheimer’s Disease Research

      • Edward W. Campion

      Pages 71-78

4. Historical, Legal, and Ethical Background

   1. Front Matter

      Pages N5-N5

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   2. Research Objectives and the Social Structuring of the Research Enterprise

      • Harry Yeide Jr.

      Pages 79-97

   3. Research on Senile Dementia of the Alzheimer’s Type

      • Christine Cassel

      Pages 99-108

   4. An Alternative Approach to Informed Consent in Research with Vulnerable Patients

      • Andrew Jameton

      Pages 109-122

   5. Technical Aspects of Obtaining Informed Consent from Persons with Senile Dementia of the Alzheimer’s Type

      • Richard M. Ratzan

      Pages 123-139

5. Institutional Issues

   1. Front Matter

      Pages N7-N7

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   2. The Need for Alternatives to Informed Consent by Older Patients

      • Pamela B. Hoffman, Leslie S. Libow

      Pages 141-148

   3. Legal Issues in Research on Institutionalized Demented Patients

      • Nancy Neveloff Dubler

      Pages 149-173

   4. Issues of Equity in the Selection of Subjects for Experimental Research on Senile Dementia of the Alzheimer’s Type

      • Harry R. Moody

      Pages 175-189

6. Competency to Give Consent

   1. Front Matter

      Pages N9-N9

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The National Institute on Aging (NIA) has historically been concerned with the protection of human subjects. In July 1977, the NIA sponsored a meeting to update and supplement guide­ lines for protecting those participating in Federal research pro­ jects. Although the basic guidelines had been in effect since 1966, it had been neglected to include the elderly as a vulnerable population. In November 1981, the NIA organized a conference on the ethical and legal issues related to informed consent in senile dementia cases. The present volume offers the latest and best thinking on Alzheimer's Dementia to have emerged from the dialog that was first embarked upon at the NIA meeting. Indeed, the issues and concerns it treats now seem even more relevant than they appeared historically because of the vastly greater awareness in the community of the entire spectrum of problems Alzheimer's disease confronts us all with. Our interest and concern is both humanitarian and self­ serving. Clearly older people must be protected from in­ appropriate research and careful attention must be paid to the circumstances under which research is conducted on those older persons who have given anything less than full consent. It is equally necessary, however, for the research enterprise to be protected so that today's elderly and those of the future can benefit from the fruits of research.

• Alzheimer
• Ethical Issues
• Ethical Perspective
• aging
• alzheimer's disease
• assessment
• autonomy
• dementia
• ethics
• morality
• perception
• respect for autonomy

• Department of Biology and the Center of Applied Research and Urban Policy, University of the District of Columbia, USA

  Vijaya L. Melnick

• Department of Social Medicine, Montefiore Medical Center, Bronx, USA

  Nancy Neveloff Dubler

Policies and ethics