Contemporary Biomedicine

The Human Teratomas

Experimental and Clinical Biology

Editors: Damjanov, Ivan, Knowles, Barbara B., Solter, Davor (Eds.)

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About this book

Human teratocarcinoma has long held a fascination to the pathologist be­ cause of the diversity of the seemingly benign differentiated tissues asso­ ciated with the tumor. An understanding of this diversity came with the demonstration of the pluripotent nature of the embryonal carcinoma cell, the stem cell of the tumor, in experimental animals. Single cell clones of murine embryonal carcinomas were derived and the resultant cell lines injected into immunosuppressed hosts, where the embryonal carcinoma stem cell itself gave rise to the wealth of differentiated tissues seen in teratocarcinomas. It was also shown that teratocarcinomas could be pro­ duced experimentally by transplantation of staged early mouse embryo to extrauterine sites; subsequent experiments suggested that the embryonal carcinoma stem cell was, in fact, comparable to a normal cell of the em­ bryonic ectoderm. Many elegant experiments have since been built on this early work; murine embryonal carcinoma cells are providing the ex­ perimental material for a first biochemical evaluation of the earliest dif­ ferentiation events in mammalian embryogenesis. In this volume, we relate the beginnings of experimental research on human teratoma. The human embryonal carcinoma cells have been char­ acterized and established in vitro, providing an experimental model to study the unique biology of these cells. Monoclonal antibodies, estab­ lished from work with these in vitro cultures, provide cell surface probes that define populations of embryonal cells and their derivatives in tumor sections.

Table of contents (1 chapter)

  • The Characteristics of Cell Lines Derived from Human Germ Cell Tumors

    Peter W. Andrews

    Pages 285-311

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Buy this book

eBook $119.00 net
( price for USA )
  • ISBN 978-1-4612-5628-1
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Hardcover $209.00 net
( price for USA )
  • ISBN 978-0-89603-040-4
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days
Softcover $149.00 net
( price for USA )
  • ISBN 978-1-4612-5630-4
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

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Bibliographic Information

Bibliographic Information
Book Title
The Human Teratomas
Book Subtitle
Experimental and Clinical Biology
Series Title
Contemporary Biomedicine
Series Volume
3
Copyright
1983
Publisher
Humana Press
Copyright Holder
The HUMANA Press Inc.
eBook ISBN
978-1-4612-5628-1
DOI
10.1007/978-1-4612-5628-1
Hardcover ISBN
978-0-89603-040-4
Softcover ISBN
978-1-4612-5630-4
Edition Number
1
Topics