Living Morphogenesis of the Heart

1. Front Matter

   Pages i-xviii

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2. Morphoregulatory Mechanisms Underlying Early Heart Development: Precardiac Stages to the Looping, Tubular Heart

   • Kersti K. Linask, James W. Lash

   Pages 1-41

3. Formation and Septation of the Tubular Heart: Integrating the Dynamics of Morphology With Emerging Molecular Concepts

   • Roger R. Markwald, Thomas Trusk, Ricardo Moreno-Rodriguez

   Pages 43-84

4. Straight Tube Heart. Primitive Cardiac Cavities vs. Primitive Cardiac Segments

   • Marίa V. de la Cruz, Concepción Sanchez-Gomez

   Pages 85-98

5. Torsion and Looping of the Cardiac Tube and Primitive Cardiac Segments. Anatomical Manifestations

   • Marίa V. de la Cruz

   Pages 99-119

6. Embryological Development of the Apical Trabeculated Region of Both Ventricles. The Contribution of the Primitive Interventricular Septum in the Ventricular Septation

   • María V. de la Cruz, Ricardo Moreno-Rodriguez

   Pages 121-130

7. Embryological Development of the Ventricular Inlets. Septation and Atrioventricular Valve Apparatus

   • María V. de la Cruz, Roger R. Markwald

   Pages 131-155

8. Embryological Development of the Outlet of Each Ventricle

   • María V. de la Cruz

   Pages 157-168

9. Embryological Development of the Atria. Septation and Visceroatrial Situs

   • Guillermo Anselmi, María Victoria de la Cruz

   Pages 169-186

10. Development of the Great Arteries

    • Karen Waldo, Margaret L. Kirby

    Pages 187-217

11. Primitive Cardiac Segment, Normal Heart, and Congenital Heart Diseases

    • María V. de la Cruz

    Pages 219-228

12. Back Matter

    Pages 229-233

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The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progres­ sively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morpho­ genesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or muItiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovas­ cular morphogenesis that will serve not only as an important archival and didactic reference source for those who have recently come into the field but also as a guide to the evolution of a field that is clearly coming of age.

• Developmental Biology
• biology
• cardiology
• cardiovascular
• congenital heart disease
• diseases
• growth
• heart

• Departamento de Biología del Desarrollo y Teratogénesis, Hospital Infantil de México “Federico Gómez”, México, México

  María Victoria Cruz

• Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, USA

  Roger R. Markwald

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