Developments in Oncology

Clinical Applications of Cytokines and Growth Factors

Editors: Wingard, John R., Demetri, George D. (Eds.)

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About this book

The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.

Table of contents (22 chapters)

  • Cytokines, Growth Factors and Hematopoiesis

    Bagby, Grover C. (et al.)

    Pages 2-55

  • The Interaction of Cytokines with Stem Cell and Stromal Cell Physiology

    Simmons, Paul J. (et al.)

    Pages 56-73

  • The Interaction of Cytokines with T cell and Natural Killer Cell Physiology

    Carter, Richard A. (et al.)

    Pages 74-89

  • Improving on Nature by Re-Engineering Hematopoietic Growth Factors

    Feng, Yiqing (et al.)

    Pages 90-116

  • The Influence of Colony-Stimulating Factors on Neutrophil Production, Distribution, and Function

    Gaviria, J. Milton (et al.)

    Pages 118-136

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-1-4615-5013-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-7923-8486-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.00
price for USA
  • ISBN 978-1-4613-7277-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Applications of Cytokines and Growth Factors
Editors
  • John R. Wingard
  • George D. Demetri
Series Title
Developments in Oncology
Series Volume
80
Copyright
1999
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-5013-6
DOI
10.1007/978-1-4615-5013-6
Hardcover ISBN
978-0-7923-8486-1
Softcover ISBN
978-1-4613-7277-6
Edition Number
1
Number of Pages
XII, 407
Topics