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Molecular Genetics of Cardiac Electrophysiology

  • Book
  • © 2000

Overview

Editors:
  1. Charles I. Berul

    1. Department of Cardiology, Children’s Hospital, Boston, USA
      Department of Pediatrics, Harvard Medical School, Boston, USA

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  2. Jeffrey A. Towbin

    1. Departments of Pediatrics (Cardiology), Molecular and Human Genetics, Texas Children’s Hospital, Baylor College of Medicine, Houston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 231)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Overview: Genetics of Cardiac Electrophysiology

    1. Overview: Genetics of Cardiac Electrophysiology

      • Jeffrey A. Towbin, Charles I. Berul
      Pages 1-2

  3. Experimental Investigation of Inherited Electrophysiological Disorders

    1. Single-Cell Electrophysiology and Ion Channelopathies

      • Coeli M. B. Lopes, Steve A. N. Goldstein, Michael Apkon
      Pages 3-21

    2. Animal Models of Inherited Electrophysiologic Diseases

      • Amit Rakhit, Charles I. Berul
      Pages 23-44

    3. Optical Mapping of Arrhythmias

      • Gregory E. Morley, Dhananjay Vaidya, JosĂ© Jalife
      Pages 45-60

    4. Connexins and Conduction

      • Deborah L. Lerner, Jeffrey E. Saffitz
      Pages 61-80

  4. Hereditary Arrhythmias

    1. Hereditary Supraventricular Tachycardias

      • Patrick Y. Jay, Charles I. Berul
      Pages 81-91

    2. Familial Atrial Fibrillation

      • Ramon Brugada, Robert Roberts
      Pages 93-100

    3. The Molecular Cardiology of Heart Block

      • Robert M. Hamilton
      Pages 101-118

  5. Ion Channel Mutations with Clinical Electrophysiologic Consequences

    1. Congenital Long QT Syndromes

      • G. Michael Vincent, Katherine Timothy
      Pages 119-135

    2. Molecular Genetics of the Acquired Long QT Syndrome

      • Dan M. Roden
      Pages 137-146

    3. Brugada Syndrome Genetics

      • Jeffrey A. Towbin, Matteo Vatta, Koonalee Nademanee, Ramon Brugada, Josep Brugada, Charles Antzelevitch et al.
      Pages 147-180

  6. Inherited Cardiomyopathies with Arrhythmias

    1. Familial Hypertrophic Cardiomyopathy Genetics

      • Laura M. Bevilacqua, Charles I. Berul
      Pages 181-194

    2. Familial Dilated Cardiomyopathy

      • Jeffrey A. Towbin, Neil E. Bowles
      Pages 195-218

    3. Glycogen Storage Diseases

      • Mira Irons, Ellen Roy Elias
      Pages 219-237

    4. Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

      • Frank I. Marcus, Peter Ott
      Pages 239-250

    5. Cardiac Disease in Duchenne and Becker Muscular Dystrophies: The Dystrophinopathies

      • Leslie B. Smoot, Gerald Cox
      Pages 251-266

    6. Myotonic Muscular Dystrophy Genetics and Cardiac Sequelae

      • Sita Reddy, Charles I. Berul
      Pages 267-286

  7. Inherited Structural Heart Diseases Associated with Arrhythmias

    1. Genetic Causes of Atrial Septal Defects

      • Kristen Patton, Christine E. Seidman
      Pages 287-296

    2. Holt-Oram Syndrome and the TBX5 Transcription Factor in Cardiogenesis

      • Cathy J. Hatcher, Craig T. Basson
      Pages 297-315
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Keywords

About this book

The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.

Editors and Affiliations

  • Department of Cardiology, Children’s Hospital, Boston, USA

    Charles I. Berul

  • Department of Pediatrics, Harvard Medical School, Boston, USA

    Charles I. Berul

  • Departments of Pediatrics (Cardiology), Molecular and Human Genetics, Texas Children’s Hospital, Baylor College of Medicine, Houston, USA

    Jeffrey A. Towbin

Bibliographic Information

  • Book Title: Molecular Genetics of Cardiac Electrophysiology

  • Editors: Charles I. Berul, Jeffrey A. Towbin

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-4517-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-7923-7829-7Published: 30 April 2000

  • Softcover ISBN: 978-1-4613-7037-6Published: 08 October 2012

  • eBook ISBN: 978-1-4615-4517-0Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XIII, 378

  • Topics: Cardiology

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