Developments in Cardiovascular Medicine

Molecular Genetics of Cardiac Electrophysiology

Editors: Berul, C., Towbin, Jeffrey A. (Eds.)

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About this book

The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.

Table of contents (22 chapters)

  • Overview: Genetics of Cardiac Electrophysiology

    Towbin, Jeffrey A. (et al.)

    Pages 1-2

  • Single-Cell Electrophysiology and Ion Channelopathies

    Lopes, Coeli M. B. (et al.)

    Pages 3-21

  • Animal Models of Inherited Electrophysiologic Diseases

    Rakhit, Amit (et al.)

    Pages 23-44

  • Optical Mapping of Arrhythmias

    Morley, Gregory E. (et al.)

    Pages 45-60

  • Connexins and Conduction

    Lerner, Deborah L. (et al.)

    Pages 61-80

Buy this book

eBook $309.00
price for USA (gross)
  • ISBN 978-1-4615-4517-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $399.00
price for USA
  • ISBN 978-0-7923-7829-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $399.00
price for USA
  • ISBN 978-1-4613-7037-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Genetics of Cardiac Electrophysiology
Editors
  • C. Berul
  • Jeffrey A. Towbin
Series Title
Developments in Cardiovascular Medicine
Series Volume
231
Copyright
2000
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-4517-0
DOI
10.1007/978-1-4615-4517-0
Hardcover ISBN
978-0-7923-7829-7
Softcover ISBN
978-1-4613-7037-6
Series ISSN
0166-9842
Edition Number
1
Number of Pages
XIII, 378
Topics