Endocrine Updates

Graves’ Disease

Pathogenesis and Treatment

Editors: Rapoport, Basil, McLachlan, Sandra M. (Eds.)

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  • ISBN 978-1-4615-4407-4
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About this book

From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete.
The chapters in Graves' Disease: Pathogenesis and Treatment represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease.

Table of contents (21 chapters)

  • Graves’ Disease — A Historical Perspective

    Volpé, Robert (et al.)

    Pages 1-8

  • Epidemiology of Graves’ Disease

    Phillips, David

    Pages 9-18

  • The Genetics of Familial and Non-Familial Hyperthyroid Graves’ Disease

    Tomer, Yaron (et al.)

    Pages 19-41

  • Thyroid Autoantibodies in Graves’ Disease

    Rapoport, Basil (et al.)

    Pages 43-66

  • T Cells and the Autoimmune Response to the TSH Receptor

    McLachlan, Sandra M. (et al.)

    Pages 67-78

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4615-4407-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $319.00
price for USA
  • ISBN 978-0-7923-7790-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4613-6983-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Graves’ Disease
Book Subtitle
Pathogenesis and Treatment
Editors
  • Basil Rapoport
  • Sandra M. McLachlan
Series Title
Endocrine Updates
Series Volume
6
Copyright
2000
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-4407-4
DOI
10.1007/978-1-4615-4407-4
Hardcover ISBN
978-0-7923-7790-0
Softcover ISBN
978-1-4613-6983-7
Series ISSN
1566-0729
Edition Number
1
Number of Pages
XIII, 307
Topics