Cancer Treatment and Research

Non-Myeloablative Allogeneic Transplantation

Editors: Bashey, Asad, Ball, Edward D. (Eds.)

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About this book

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Table of contents (9 chapters)

  • Development of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

    Castro, Januario E. (et al.)

    Pages 1-37

  • Immunosuppression with Limited Toxicity: The Characteristics of Nucleoside Analogs and Anti-Lymphocyte Antibodies Used in Nonmyeloablative Hematopoietic Cell Transplantation

    Bashey, Asad

    Pages 39-49

  • Mobilization of Allogeneic Peripheral Blood Progenitor Cells

    Law, Ping (et al.)

    Pages 51-77

  • Non-Myeloblative Induction of Mixed Hematopoietic Chimerism: Application to Transplantation Tolerance and Hematologic Malignancies in Experimental and Clinical Studies

    Sykes, Megan (et al.)

    Pages 79-99

  • Combined Use of Auto-Grafting and Non-Myeloablative Allografting for the Treatment of Hematologic Malignancies and Metastatic Breast Cancer

    Carella, Angelo M. (et al.)

    Pages 101-112

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-1-4615-0919-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-7923-7646-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-1-4613-5304-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Non-Myeloablative Allogeneic Transplantation
Editors
  • Asad Bashey
  • Edward D. Ball
Series Title
Cancer Treatment and Research
Series Volume
110
Copyright
2002
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-0919-6
DOI
10.1007/978-1-4615-0919-6
Hardcover ISBN
978-0-7923-7646-0
Softcover ISBN
978-1-4613-5304-1
Series ISSN
0927-3042
Edition Number
1
Number of Pages
X, 216
Topics