RNA Binding Proteins

1. Front Matter

   Pages i-xv

   PDF

2. Translational Control

   1. The Role of RNA-Binding Proteins in IRES-Dependent Translation

      • Sung Key Jang, Eckard Wimmer

      Pages 1-33

   2. Translational Regulation of Masked Maternal mRNAs in Early Development

      • Nancy Standart

      Pages 35-51

   3. Poly-C Binding Proteins: Cellular Regulators of mRNA Fate and Function

      • Andrea V. Gamarnik, Raul Andino

      Pages 53-69

   4. Autoregulation of Protein Synthesis by Translation

      • Guim Kwon, Guang Xu, Wilhelm S. Cruz, Connie A. Marshall, Michael L. McDaniel

      Pages 71-86

   5. Translational Initiation of Ornithine Decarboxylase mRNA

      • Lo Persson, Koichi Takao

      Pages 87-100

3. mRNA Metabolism

   1. Regulation of mRNA Stability by AUF1

      • Gerald M. Wilson, Gary Brewer

      Pages 101-117

   2. RNA Binding by Members of the 70-kDa Family of Molecular Chaperones

      • Christine Zimmer, Eszter Nagy, John Subjeck, Tamás Henics

      Pages 119-134

   3. Post-Transcriptional Control of Type-1 Plasminogen Activator Inhibitor mRNA

      • Joanne H. Heaton, Thomas D. Gelehrter

      Pages 135-156

   4. Post-Transcriptional Control of the GAP-43 mRNA by the ELAV-Like Protein HuD

      • Nora Perrone-Bizzozero, Rebecca Keller

      Pages 157-174

4. Hormonal and Homeostatic Regulation

   1. RNA-Dependent Protein Kinases

      • Raymond A. Petryshyn, Sergie Nekhai, Evelio D. Perez-Albuerne

      Pages 175-191

   2. Regulation of Messenger Rna-Binding Proteins by Protein Kinases A and C

      • Richard A. Jungmann

      Pages 193-211

   3. Post-Transcriptional Regulation of Iron Metabolism

      • Tracey A. Rouault

      Pages 213-224

   4. Cytochrome P450 RNA—Protein Interactions

      • Matti A. Lang, Françoise Raffalli-Mathieu

      Pages 225-238

   5. Site-Specific Cleavage of Insulin-Like Growth Factor II mRNAs

      • Erwin L. van Dijk, P. Elly Holthuizen

      Pages 239-254

   6. Hormonal Regulation of the EGF/Receptor System

      • Stephen W. Spaulding, Lowell G. Sheflin

      Pages 255-270

   7. The Role of RNA Binding Proteins in Tumorigenesis

      • Sreerama Shetty

      Pages 271-284

   8. Regulation of G-Protein Coupled Receptor Cytosolic mRNA Binding Proteins

      • Kathryn Sandberg, Zheng Wu, Hong Ji, Eric Hernandez, Susan E. Mulroney

      Pages 285-306

5. Back Matter

   Pages 307-308

   PDF

RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins.
Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.

• DNA
• G proteins
• RNA
• Translation
• gene expression
• genes
• growth factor
• insulin
• insulin-like
• metabolism
• proteins
• transcription
• diabetes

• Departments of Medicine and Physiology & Biophysics, Georgetown University School of Medicine, USA

  Kathryn Sandberg

• Department of Physiology & Biophysics, Georgetown University School of Medicine, USA

  Susan E. Mulroney

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