Endocrine Updates

Thyroid Eye Disease

Editors: Bahn, Rebecca (Ed.)

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About this book

Patients aftlicted with thyroid eye disease or Graves' ophthamopathy (GO) may experience not only pain and visual loss, but also disfigurement. Full understanding of pathogenesis has been elusive, and treatment modalities are imperfect. As with other conditions, more effective intervention will follow only after a better understanding of pathogenesis is reached. The goal of this volume is to give an overview by leaders in the field of the present state of the art both in pathogenesis and clinical aspects of GO. Much attention has been directed towards determining which cells within the orbit are targets of the autoimmune process, and how these and other cells might participate in the local inflammatory process. It is now generally agreed that orbital fibroblasts, preadipocyte fibroblasts, and adipocytes are the targeted and activated cells in GO and that full-length TSH receptor (TSHr) is expressed in these cells. Further, there is growing consensus that this receptor is up-regulated in the orbit in GO, residing primarily in newly differentiated adipocytes. However, it is also evident, given a sufficiently sensitive assay, that TSHr is detectable in fibroblasts and adipocytes from the normal orbit and other anatomic sites, as well. It will be important to determine whether the observed increase in orbital TSHr expression itself initiates the orbital autoimmune process. Also to be decided is whether orbital lymphocytes from GO patients specifically recognize this receptor, and what factor or factors unique to Graves' dIsease might stimulate TSHr expression in orbital cells.

Reviews

`Of interest to general endocrinologists, pediatric endocrinologists and ophthalmologists '
Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)

Table of contents (14 chapters)

  • Orbital Autoantigens

    Weetman, Anthony P. (et al.)

    Pages 1-20

  • Orbital Autoimmunity in Graves’ Disease

    Heufelder, Armin E. (et al.)

    Pages 21-36

  • Adipogenesis and TSH Receptor Expression

    Munsakul, Natee (et al.)

    Pages 37-44

  • Role of Cytokines in the Pathogenesis of Graves’ Ophthalmopathy

    Hiromatsu, Yuji (et al.)

    Pages 45-65

  • Animal Models of Graves’ Ophthalmopathy

    Ludgate, Marian (et al.)

    Pages 67-81

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-4615-1447-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-0-7923-7380-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA
  • ISBN 978-1-4613-5558-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Thyroid Eye Disease
Editors
  • Rebecca Bahn
Series Title
Endocrine Updates
Series Volume
14
Copyright
2001
Publisher
Springer US
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-1-4615-1447-3
DOI
10.1007/978-1-4615-1447-3
Hardcover ISBN
978-0-7923-7380-3
Softcover ISBN
978-1-4613-5558-8
Series ISSN
1566-0729
Edition Number
1
Number of Pages
XII, 253
Topics