Endocrine Updates

Molecular Basis of Pancreas Development and Function

Editors: Habener, Joel F., Hussain, Mehboob (Eds.)

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About this book

Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.

Reviews

`A very interesting text for both research and clinical endocrinologists.'
Journal of Pediatric Endocrinology and Metabolism, 15:4 (2002)

Table of contents (23 chapters)

  • An Historical and Phylogenetic Perspective of Islet-Cell Development

    Madsen, Ole D. (et al.)

    Pages 1-17

  • Glucose signalling to Transcription factors of the Insulin gene

    Melloul, Danielle

    Pages 19-33

  • β-Cell Dysfunction and Chronic Hyperglycaemia

    Leahy, Jack L.

    Pages 35-46

  • Glucose Toxicity of the Pancreatic ß-Cell

    Robertson, R. Paul (et al.)

    Pages 47-66

  • The α-Cell and Regulation of Glucagon Gene Transcription

    Knepel, Willchart

    Pages 67-89

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-1-4615-1669-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-7923-7271-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4613-5669-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Basis of Pancreas Development and Function
Editors
  • Joel F. Habener
  • Mehboob Hussain
Series Title
Endocrine Updates
Series Volume
11
Copyright
2001
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-1669-9
DOI
10.1007/978-1-4615-1669-9
Hardcover ISBN
978-0-7923-7271-4
Softcover ISBN
978-1-4613-5669-1
Series ISSN
1566-0729
Edition Number
1
Number of Pages
XIV, 412
Topics