Developments in Nuclear Medicine

Imaging of Hypoxia

Tracer Developments

Editors: Machulla, Hans-Jürgen (Ed.)

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About this book

Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem.
As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.

Reviews

`Overall, this text provides a summary of the status of radionuclide imaging of hypoxia. The material is clearly prestented, well referenced and authoritative. The text is concise, and should serve as a reference for investigators interested in pursuing work in this field.'
European Journal of Nuclear Medicine 28:5,(2001)

Table of contents (9 chapters)

  • Hypoxia: an Introduction

    Wiebe, Leonard I. (et al.)

    Pages 1-18

  • The Biology of Technetium Based Hypoxic Tissue Localising Compounds

    Nunn, Adrian D.

    Pages 19-45

  • Basic Chemistry of 2-Nitroimidazoles (Azomycin Derivatives)

    Müller, Christa E.

    Pages 47-59

  • Molecular Design Approaches of Hypoxia Tracers

    Folkers, Gerd (et al.)

    Pages 61-74

  • Syntheses of PET-Tracers for the Determination of Hypoxia

    Grierson, John (et al.)

    Pages 75-84

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-94-017-1828-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-0-7923-5529-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-90-481-5157-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Imaging of Hypoxia
Book Subtitle
Tracer Developments
Editors
  • Hans-Jürgen Machulla
Series Title
Developments in Nuclear Medicine
Series Volume
33
Copyright
1999
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-1828-8
DOI
10.1007/978-94-017-1828-8
Hardcover ISBN
978-0-7923-5529-8
Softcover ISBN
978-90-481-5157-8
Edition Number
1
Number of Pages
XX, 180
Topics