Developments in Nuclear Medicine

Current Directions in Radiopharmaceutical Research and Development

Editors: Mather, Steven J. (Ed.)

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About this book

Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.

Reviews

` ... very good reference text ... a very useful book, especially as an aid to teachers or in providing an overall picture of fast developing new didrections in radiopharmaceutical research.'
ANZ Nuclear Medicine, 23 (1997)

Table of contents (14 chapters)

  • Radiopharmaceutically Relevant Chemistry of Technetium and Rhenium

    Dilworth, Jonathan R. (et al.)

    Pages 1-29

  • Bifunctional Chelators for Technetium-99m

    Verbruggen, Alfons M.

    Pages 31-46

  • Medium Half-Life Inorganic Radionuclides for Pet Imaging

    Zweit, Jamal

    Pages 47-61

  • Therapeutic Radionuclides: Making the Right Choice

    Srivastava, Suresh C.

    Pages 63-79

  • Radiopharmaceuticals for Imaging Hypoxia

    Archer, Colin M. (et al.)

    Pages 81-88

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-94-009-1768-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-7923-4254-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-94-010-7289-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Current Directions in Radiopharmaceutical Research and Development
Editors
  • Steven J. Mather
Series Title
Developments in Nuclear Medicine
Series Volume
30
Copyright
1996
Publisher
Springer Netherlands
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-94-009-1768-2
DOI
10.1007/978-94-009-1768-2
Hardcover ISBN
978-0-7923-4254-0
Softcover ISBN
978-94-010-7289-2
Edition Number
1
Number of Pages
XVI, 240
Topics