Developments in Nuclear Medicine

Biological Models in Radiopharmaceutical Development

Authors: Lambrecht, R.M.

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About this book

Radiophannaceuticals labeled with short-lived radionuclides are utilized to unravel biochemical processes, and to diagnosis and treat diseases of the living body are-developed through extensive evaluation in ~iological models. 'fhC first attempt to compile information was a volume entitled ANIMAL MODELS IN RADIOTRACER DESIGN that was edited by William C. Eckelman and myself in 1983. The volume had a focus on the animal models that investigators were using in order to design radiotracers that displayed in vivo selectivity as measured by biodistribution and pharmacokinetic studies. A concern in the early days of nuclear medicine was species differences. Often a series of labeled compounds were evaluated in a several different animal models in order to gain confidence that the selected radiotracer would behave appropriately in humans. During the past 12 years there have been remarkable advances in molecular genetics, molecular biology, synthetic radiopharmaceutical chemistry, molecular modeling and visualization, and emission tomography. Biological models can now be selected that are better defined in terms of molecular aspects of the disease process. The development of high resolution PET and SPET for clinical applications facilitates the development of new radiopharmaceuticals by the use of models to quantitatively evaluate drug effects, and progression of disease, and hence to arrive at better diagnosis and treatments for animals and humans. With these advances there is an effective use of biological models, and the refinement of alternatives for the development of new radiophannaceuticals.

Reviews

`This is an original and unique reference book with high practical value for researchers in the field. Those who have dealt with the problem of finding an appropriate animal model for a certain study will especially appreciate this book. This book is an absolute `must' for those involved in preclinical development and biological testing of radiopharmaceuticals.'
European Journal of Nuclear Medicine, 23:7 (1996)

Table of contents (4 chapters)

  • Introduction

    Lambrecht, Richard M.

    Pages 1-10

  • Design of Candidate Radiopharmaceuticals

    Lambrecht, Richard M.

    Pages 11-15

  • Concept of Biological Model

    Lambrecht, Richard M.

    Pages 16-35

  • Tomographic Physiological Chemistry

    Lambrecht, Richard M.

    Pages 36-47

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-94-009-0159-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
  • ISBN 978-0-7923-3836-9
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $99.00
price for USA
  • ISBN 978-94-010-6558-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Biological Models in Radiopharmaceutical Development
Authors
Series Title
Developments in Nuclear Medicine
Series Volume
27
Copyright
1996
Publisher
Springer Netherlands
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-94-009-0159-9
DOI
10.1007/978-94-009-0159-9
Hardcover ISBN
978-0-7923-3836-9
Softcover ISBN
978-94-010-6558-0
Edition Number
1
Number of Pages
XI, 272
Topics