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Basic and Clinical Applications of Flow Cytometry

Proceeding of the 24th Annual Detroit Cancer Symposium Detroit, Michigan, USA - April 30, May 1 and 2, 1992

  • Conference proceedings
  • © 1996

Overview

Editors:
  1. Frederick A. Valeriote

    1. Division of Hematology and Oncology, School of Medicine, Wayne State University, Detroit, USA

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  2. Alexander Nakeff

    1. Division of Hematology and Oncology, School of Medicine, Wayne State University, Detroit, USA

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  3. Manuel Valdivieso

    1. Division of Hematology and Oncology, School of Medicine, Wayne State University, Detroit, USA

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Part of the book series: Developments in Oncology (DION, volume 77)

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Table of contents (18 papers)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Cytometry 2000: Laser Probing the Future

    • Alexander Nakeff
    Pages 1-3

  3. Activation and Proliferation of Purified Hematopoietic Precursor Cells from Human Bone Marrow

    • P. Lansdorp, W. Dragowska, T. Thomas
    Pages 5-12

  4. Flow Cytometric Proliferative Fraction Analysis in Solid Tumors

    • Daniel W. Visscher, Susan M. Wykes, John D. Crissman
    Pages 13-32

  5. Mitogenic and Non-Mitogenic Induction of Lymphocytic Invasion: Dual Parameter flow Cytometric Analysis

    • S. Ratner, D. Lichlyter
    Pages 33-47

  6. Flow Cytometric Monitoring of Drug Resistance in Human Solid Tumors

    • Awtar Krishan, Cheppail Ramachandran, Antonieta Sauerteig
    Pages 49-64

  7. Flow Cytometry in Oncology: Some Lessons from History

    • Howard M. Shapiro
    Pages 65-80

  8. DNA Flow Cytometry Application to Clinical Trials in Breast Cancer

    • Lynn G. Dressler
    Pages 81-93

  9. Processing of Solid Tumors for DNA Analysis by Flow Cytometry

    • Charles L. Hitchcock, John F. Ensley, Mark Zalupski
    Pages 95-123

  10. SJL Model for Lymphoma Treatment

    • M. Cankovic, T. Wrone-Smith, E. VanBuren, S. Lerman
    Pages 125-142

  11. Gene Mapping and Molecular Cytogenetics Using Flow-Sorted Chromosomes

    • N. P. Carter
    Pages 143-158

  12. The Clinical Potential of DNA Content Parameters in Human Pediatric and Adult Solid Tumors

    • Mark Zalupski, John F. Ensley
    Pages 159-178

  13. Differentiation of Human B-Cell Tumors: A Preclinical Model for Differentiation Therapy

    • Ayad M. Al-Katib, Ramzi Mohammad
    Pages 179-195

  14. Probing Immune Responses: The Role of Intracellular Glutathione

    • Mario Roederer, Leonard A. Herzenberg
    Pages 197-210

  15. DNA Topoisomerase II Poisons and the Cell Cycle

    • P. J. Smith
    Pages 211-225

  16. In Situ Hybridization of Centromeric DNA as Visualized on the Nuclear Matrix by Laser Confocal Cytometry

    • Kenneth J. Pienta
    Pages 227-238

  17. Megakaryocytopoiesis 2000

    • Alexander Nakeff
    Pages 239-250

  18. The Molecular Basis for the Control of Mammalian Cell Growth

    • Gerard I. Evan
    Pages 251-269

  19. Isolation of Rare Cells by High-Speed Flow Cytometry and High-Resolution Cell Sorting for Subsequent Molecular Characterization - Applications in Prenatal Diagnosis, Breast Cancer and Autologous Bone Marrow Transplantation

    • James F. Leary, Donald Schmidt, Janet G. Gram, Scott R. McLaughlin, Camille Dallatorre, Stefan Burde et al.
    Pages 271-318
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Keywords

About this book

The focus of this symposium was on the present and future capabilities of flow cytometry for both medical and biological applications in cancer. This technology began with quite modest instrumentation, with limited capabilities to answer biological questions. Today, both the clinical workhorses and the powerful multi-laser, multi-detector, sorting machinery, coupled with sophisticated computers and storage devices and the increasing storehouse of markers and dyes, are taking us to the limit and beyond in finding answers to the cause and cure of cancer.
In the past, both normal hematopoietic tissue and leukemias have been the tissue samples of choice in the application of flow cytometry, and some of the most recent applications with these tissues are presented here. However, the book also discusses the increasingly sophisticated disaggregation techniques which allow investigators the possibility to train their lasers on solid tumors. Not only can we use flow cytometry with associated fluorescent markers to understand the biology of cancer, but also the wide array of existing and developing markers provides us with important diagnostic tools in the detection of cancer early in either the malignant or relapse process. And the field comes full circle, with the use of the technology for gene mapping and other genetic studies to unlock the basic malignant process.

Editors and Affiliations

  • Division of Hematology and Oncology, School of Medicine, Wayne State University, Detroit, USA

    Frederick A. Valeriote, Alexander Nakeff, Manuel Valdivieso

Bibliographic Information

  • Book Title: Basic and Clinical Applications of Flow Cytometry

  • Book Subtitle: Proceeding of the 24th Annual Detroit Cancer Symposium Detroit, Michigan, USA - April 30, May 1 and 2, 1992

  • Editors: Frederick A. Valeriote, Alexander Nakeff, Manuel Valdivieso

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4613-1253-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1996

  • Hardcover ISBN: 978-0-7923-3809-3Published: 31 December 1995

  • Softcover ISBN: 978-1-4612-8534-2Published: 17 September 2011

  • eBook ISBN: 978-1-4613-1253-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 318

  • Topics: Oncology, Cancer Research, Laboratory Medicine

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