Cancer Treatment and Research

Concepts, Mechanisms, and New Targets for Chemotherapy

Editors: Muggia, Franco M. (Ed.)

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About this book

Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity.
Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways.
Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.

Table of contents (10 chapters)

  • Potential for protein kinase C inhibitors in cancer therapy

    Philip, Philip A. (et al.)

    Pages 3-27

  • Recent clinical advances with camptothecin analogues

    Slichenmyer, William J. (et al.)

    Pages 29-43

  • The reversal of multidrug resistance

    Fisher, George A. (et al.)

    Pages 45-70

  • Fluoropyrimidine catabolism

    Diasio, Robert B. (et al.)

    Pages 71-93

  • Use of hydroxyurea to alter drug resistance of human tumor cells

    Berg, Carla (et al.)

    Pages 95-114

Buy this book

eBook $299.00
price for USA (gross)
  • ISBN 978-1-4615-2007-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $379.00
price for USA
  • ISBN 978-0-7923-3525-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $379.00
price for USA
  • ISBN 978-1-4613-5829-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Concepts, Mechanisms, and New Targets for Chemotherapy
Editors
  • Franco M. Muggia
Series Title
Cancer Treatment and Research
Series Volume
78
Copyright
1995
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-2007-8
DOI
10.1007/978-1-4615-2007-8
Hardcover ISBN
978-0-7923-3525-2
Softcover ISBN
978-1-4613-5829-9
Series ISSN
0927-3042
Edition Number
1
Number of Pages
X, 237
Topics